The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa
The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa
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DOI：
10.1167/iovs.61.4.41
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发表时间：
2020-04-01
影响因子：
4.4
通讯作者：
Nguyen, Thao D.
中科院分区：
文献类型：
--
作者：
Midgett, Dan;Liu, Baiyun;Nguyen, Thao D.
目的.测量离体人视神经乳头压力诱导的应变反应，并分析其变化与青光眼诊断和视神经轴突损伤的关系。对8例确诊为青光眼的供体的16只眼和6例无青光眼病史的供体的10只眼的后巩膜进行5 ~ 45 mm Hg的充气试验。检查来自每个供体的视神经的轴突损失程度。筛板（LC）的后部体积用二次谐波产生成像，并使用体积相关性进行分析，以计算5和10以及5和45 mm Hg之间的LC应变。青光眼患者的眼长和LC面积明显大于正常人（P
PURPOSE. To measure the ex vivo pressure-induced strain response of the human optic nerve head and analyze for variations with glaucoma diagnosis and optic nerve axon damage.METHODS. The posterior sclera of 16 eyes from 8 diagnosed glaucoma donors and 10 eyes from 6 donors with no history of glaucoma were inflation tested between 5 and 45 mm Hg. The optic nerve from each donor was examined for degree of axon loss. The posterior volume of the lamina cribrosa (LC) was imaged with second harmonic generation and analyzed using volume correlation to calculate LC strains between 5 and 10 and 5 and 45 mm Hg.RESULTS. Eye length and LC area were larger in eyes diagnosed with glaucoma (P