Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects
Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects
复制标题
胎盘中特定持久性有机污染物与神经管缺陷风险的关联
DOI：
10.1073/pnas.1105209108
复制
发表时间：
2011-08-02
影响因子：
11.1
通讯作者：
Zhu, Tong
中科院分区：
文献类型：
--
作者：
Ren, Aiguo;Qiu, Xinghua;Zhu, Tong
持久性有机污染物（POP）与广泛的不利健康影响有关。我们的病例对照研究是为了探讨胎盘中选定的持久性有机污染物的水平和神经管缺陷（NTDs）的患病率高的中国人群的风险之间的关联。病例包括80例NTD胎儿或新生儿，而对照组为50例健康，非畸形新生儿。胎盘多环芳烃（PAHs），有机氯农药，多氯联苯，多溴联苯醚的浓度进行了分析，气相色谱-质谱法。病例胎盘中多环芳烃、二氯二苯基三氯乙烷（DDT）及其代谢物、α-和γ-六氯环己烷（HCH）和α-硫丹的中位值明显高于对照组。PAH浓度高于中位数与任何NTD的风险增加4.52倍（95%置信区间（CI），2.10-9.74）相关，无脑畸形和脊柱裂的风险分别增加5.84倍（95% CI，2.28-14.96）和3.71倍（95% CI，1.57-8.79）。PAH水平与NTD风险之间存在剂量反应关系，第二、第三和第四个四分位数与第一个四分位数相比的比值比分别为1.77倍（95% CI，0.66-4.76）、3.83倍（95% CI，1.37-10.75）和11.67倍（95% CI，3.28-41.49）。在无脑畸形和脊柱裂亚型中观察到剂量-反应关系。在o，p '-滴滴涕及其代谢物-甲型六氯环己烷、γ-六氯环己烷和甲型硫丹中也观察到了类似的结果，而在后两种污染物中没有观察到剂量-反应关系。胎盘中多环芳烃、o，p '-滴滴涕及其代谢物和甲型六氯环己烷浓度的升高与这一人群中NTD风险的增加有关。
Persistent organic pollutants (POPs) have been associated with a wide range of adverse health effects. Our case-control study was performed to explore the association between placental levels of selected POPs and risks for neural tube defects (NTDs) in a Chinese population with a high prevalence of NTDs. Cases included 80 fetuses or newborns with NTDs, whereas the controls were 50 healthy, nonmalformed newborn infants. Placental concentrations of polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers were analyzed by gas chromatography-mass spectrometry. The medians of PAHs, o,p'-isomers of dichlorodiphenyltrichloroethane (DDT) and metabolites, alpha- and gamma-hexachlorocyclohexane (HCH), and alpha-endosulfan were significantly higher in case placentas than in controls. PAH concentrations above the median were associated with a 4.52-fold (95% confidence interval (CI), 2.10-9.74) increased risk for any NTDs, and 5.84-(95% CI, 2.28-14.96) and 3.71-fold (95% CI, 1.57-8.79) increased risks for anencephaly and spina bifida, respectively. A dose-response relationship was observed between PAH levels and the risk of NTDs, with odds ratios for the second, third, and fourth quartiles, compared with the first, of 1.77-(95% CI, 0.66-4.76), 3.83-(95% CI, 1.37-10.75), and 11.67-fold (95% CI, 3.28-41.49), respectively. A dose-response relationship was observed for anencephaly and spina bifida subtypes. Similar results were observed for o,p'-DDT and metabolites, alpha-HCH, gamma-HCH, and alpha-endosulfan, whereas no dose-response relationship was observed for the last two pollutants. Elevated placental concentrations of PAHs, o,p'-DDT and metabolites, and alpha-HCH were associated with increased risks of NTDs in this population.