Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
复制标题
DOI：
10.3390/toxins12010015
复制
发表时间：
2020-01-01
期刊：
影响因子：
4.2
通讯作者：
Luo, Lei
中科院分区：
文献类型：
--
作者：
Chang, Jiajia;He, Xiaoqin;Luo, Lei
前动力蛋白是一个高度保守的小肽家族，在所有脊椎动物中都有表达，具有广泛的功能。本研究对从景东湍蛙（Amolops jingdongensis）毒液中分离到的前动力素（prokineticin）同系物（Bv 8-AJ）进行了全面的鉴定。Bv 8-AJ通过促进炎症期的启动和终止，促进小鼠全层创面的愈合。此外，Bv 8-AJ通过激活白细胞介素（IL）-1的产生，对从新生小鼠分离的成纤维细胞和角质形成细胞产生强烈的增殖作用。我们的研究结果表明，Bv 8是一种有效的伤口愈合调节剂，并可能揭示两栖动物皮肤快速伤口愈合的机制。
Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds healing of mice model by promoting the initiation and the termination of inflammatory phase. Moreover, Bv8-AJ exerted strong proliferative effect on fibroblasts and keratinocytes isolated from newborn mice by activating interleukin (IL)-1 production. Our findings indicate that Bv8 is a potent wound healing regulator and may reveal the mechanism of rapid wound-healing in amphibian skins.