Pericytes for Therapeutic Bone Repair.
Pericytes for Therapeutic Bone Repair.
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用于治疗性骨修复的周细胞。
DOI：
10.1007/978-3-030-02601-1_3
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发表时间：
2018
影响因子：
--
通讯作者：
Péault,Bruno
中科院分区：
文献类型：
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作者：
Meyers,CarolynA;Casamitjana,Joan;Chang,Leslie;Zhang,Lei;James,AaronW;Péault,Bruno
除了在血管生成和血压调节方面的精液功能外，微血管周细胞还具有潜在的组织再生潜力，在转化为间充质干细胞后的培养中可以发现这一潜力。从脂肪组织中提取的周细胞和其他相关的血管周围细胞具有强大的成骨能力，为改进骨组织工程和改进骨折和其他骨缺损的细胞治疗提供了强大而丰富的细胞来源。体内各种骨形成实验的应用，包括小鼠肌肉袋成骨和颅骨补充、大鼠和狗脊柱融合、大鼠骨不连愈合，证实了纯化的血管周围细胞用于骨骼(Re)生成的优越性。然而，令人惊讶的是，尽管有强大的内源性骨形成潜力，血管周围细胞基本上是通过当地骨祖细胞分泌因子的招募间接驱动骨再生。
Besides seminal functions in angiogenesis and blood pressure regulation, microvascular pericytes possess a latent tissue regenerative potential that can be revealed in culture following transition into mesenchymal stem cells. Endowed with robust osteogenic potential, pericytes and other related perivascular cells extracted from adipose tissue represent a potent and abundant cell source for refined bone tissue engineering and improved cell therapies of fractures and other bone defects. The use of diverse bone formation assays in vivo, which include mouse muscle pocket osteogenesis and calvaria replenishment, rat and dog spine fusion, and rat non-union fracture healing, has confirmed the superiority of purified perivascular cells for skeletal (re)generation. As a surprising observation though, despite strong endogenous bone-forming potential, perivascular cells drive bone regeneration essentially indirectly, via recruitment by secreted factors of local osteo-progenitors.