DNA double-strand break repair functions defend against parvovirus infection.
DNA double-strand break repair functions defend against parvovirus infection.
复制标题
DNA双链断裂修复功能可防御细小病毒感染。
DOI：
10.1128/jvi.70.9.6446-6449.1996
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Rhode,SL
中科院分区：
文献类型：
--
作者：
Tauer,TJ;Schneiderman,MH;Vishwanatha,JK;Rhode,SL
We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.
