Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus
Serum uric acid is associated with arterial stiffness in men with newly diagnosed type 2 diabetes mellitus
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DOI：
10.1007/s40618-013-0034-9
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发表时间：
2014-01
影响因子：
5.4
通讯作者：
Jie Zhang;G. Xiang;L. Xiang;H. Sun
中科院分区：
文献类型：
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作者：
Jie Zhang;G. Xiang;L. Xiang;H. Sun
背景糖尿病患者血尿酸水平升高和血管粥样硬化非常常见。然而，很少有研究集中在血尿酸和主动脉或外周动脉僵硬度在新诊断的糖尿病患者之间的关系。本研究旨在探讨男性初诊2型糖尿病（T2 DM）患者血尿酸水平与颈动脉-股动脉脉搏波传导速度（cfPWV）和颈动脉-桡动脉脉搏波传导速度（cr PWV）的关系。测量cfPWV和crPWV以及人体测量参数、血压、血尿酸、血糖、空腹胰岛素、C反应蛋白和血脂。高UA组cfPWV和crPWV明显高于正常对照组。血尿酸与cfPWV显著相关（r= 0.533，P < 0.001），crPWV（r= 0.334，P = 0.001），腰围（r= 0.350，P < 0.001），腰臀比（r= 0.254，P = 0.009），空腹胰岛素（r= 0.432，P < 0.001），HOMA-IR（r= 0.173，P = 0.042），空腹血糖校正年龄后，血红蛋白A1 c（r =-0.202，P = 0.038）和高密度脂蛋白胆固醇（r =-0.267，P = 0.006）。逐步多元回归分析显示，cfPWV的独立决定因素是血尿酸、年龄、C反应蛋白、HDL胆固醇和吸烟状况。而crPWV的独立决定因素是血尿酸、年龄、舒张压和HDL-cholesterol.ConclusionsSerum尿酸与T2 DM男性患者早期主动脉和外周动脉僵硬度增加显著相关。
BackgroundIncreased serum uric acid levels and vascular atherosclerosis are very common in diabetes. However, few studies focused on the relationship between serum uric acid and aortic or peripheral arterial stiffness in newly diagnosed diabetic patients. This study investigated the association between serum uric acid levels and carotid–femoral pulse wave velocity (cfPWV) or carotid–radial (cr) PWV in male patients with newly diagnosed type 2 diabetes mellitus (T2DM).Methods106 male patients with newly diagnosed T2DM were recruited. cfPWV and crPWV as well as anthropometric parameters, blood pressure, serum uric acid, blood glucose, fasting insulin, C-reactive protein and blood lipids were measured.ResultsThe subjects were divided into low uric acid (UA) subgroup and high UA subgroup according to uric acid median. cfPWV and crPWV were significantly higher in high UA subgroup. Serum uric acid significantly correlated with cfPWV (r= 0.533,P< 0.001), crPWV (r= 0.334,P= 0.001), waist circumference (r= 0.350,P< 0.001), waist-to-hip ratio (r= 0.254,P= 0.009), fasting insulin (r= 0.432,P< 0.001), HOMA-IR (r= 0.173,P= 0.042), fasting blood glucose (r= −0.271,P= 0.005), haemoglobin A1c (r= −0.202,P= 0.038), and HDL-cholesterol (r= −0.267,P= 0.006) after correction for age. Stepwise multiple regressions showed that the independent determinants of cfPWV were serum uric acid, age, C-reactive protein, HDL-cholesterol, and smoking status. And the independent determinants of crPWV were serum uric acid, age, diastolic blood pressure, and HDL-cholesterol.ConclusionsSerum uric acid is significantly associated with increased aortic and peripheral arterial stiffness in men with T2DM at the early stage.