Demonstration of local immunosuppression with methylprednisolone in the sponge matrix allograft model.
Demonstration of local immunosuppression with methylprednisolone in the sponge matrix allograft model.
复制标题
在海绵基质同种异体移植模型中展示甲基泼尼松龙的局部免疫抑制。
DOI：
10.1097/00007890-199108000-00026
复制
发表时间：
1991
期刊：
影响因子：
6.2
通讯作者：
Ascher,NL
中科院分区：
文献类型：
--
作者：
Freise,CE;Clemmings,S;Clemens,LE;Alan,T;Ashby,T;Ashby,E;Burke,EC;Roberts,JP;Ascher,NL
本研究评价了局部给予甲基强的松龙对海绵基质同种异体移植模型中全身和局部免疫应答的影响。聚氨酯海绵用DBA/2（H-2 d）或C57 B1/6小鼠（H-2 B）的腹膜渗出物细胞包被，并在24小时后皮下放置在C57 BL/6受体中。每只小鼠接受同基因和同种异体海绵移植物。通过在第0天放置含有增加量的控释MP制剂的纤维素/基质丸剂或通过每日海绵内注射MP来实现局部免疫抑制。
This study evaluated the effect of locally delivered methylprednisolone on the systemic and local immune response in the sponge matrix allograft model. Polyurethane sponges were coated with peritoneal exudate cells from DBA/2 (H-2 d) or C57B1/6 mice (H-2 b) and placed subcutaneously in C57BL/6 recipients 24 hr later. Each mouse received both a syngeneic and an allogeneic sponge graft. Local immunosuppression was effected by placement on day 0 of cellulose/matrix pellets containing a preparation of increasing quantity of controlled release MP or by daily intrasponge injection of MP.