Concordance of Direct and Indirect Measures of Medication Adherence in A Treatment Trial for Cannabis Dependence
Concordance of Direct and Indirect Measures of Medication Adherence in A Treatment Trial for Cannabis Dependence
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DOI：
10.1016/j.jsat.2015.05.002
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发表时间：
2015-10-01
影响因子：
3.9
通讯作者：
Norton, Jessica
中科院分区：
文献类型：
--
作者：
McRae-Clark, Aimee L.;Baker, Nathaniel L.;Norton, Jessica
目前的研究比较了大麻依赖药物治疗试验参与者（n = 109）中通过两种间接测量方法（药丸计数和每日用药日记）与两种直接测量方法（尿核黄素和血清 6-OH-丁螺环酮水平测量）测量的依从率。在整个研究过程中，药丸计数和日记数据显示出较高的一致性百分比和较强的卡帕系数。与药丸计数和自我报告相比，核黄素水平表明研究期间的依从性百分比较低。在 6-OH-丁螺环酮水平的参与者子集中 (n = 58)，kappa 系数也显示出药丸计数和 6-OH-丁螺环酮水平的用药日记之间的低至中等一致性。与药丸计数和用药日记相比，通过核黄素和 6-OH-丁螺环酮测量的依从性随着时间的推移显着下降。这项研究的结果支持了之前的工作，表明药丸计数和患者服用药物的自我报告可能高估了药物依从率，并且随着临床试验持续时间的增加可能变得不太可靠。 (C) 2015 Elsevier Inc. 保留所有权利。
The current study compared adherence rates as measured by two indirect measurement methods (pill count and daily medication diary) to two direct measurement methods (urine riboflavin and serum 6-OH-buspirone level measurement) among participants (n = 109) in a medication treatment trial for cannabis dependence. Pill count and diary data showed high levels of percent agreement and strong kappa coefficients throughout the study. Riboflavin levels indicated lower level of percent in adherence during the study as compared to both pill count and self-report. In the subset of participants with 6-OH-buspirone levels (n = 58), the kappa coefficient also showed low to moderate agreement between the pill count and medication diaries with 6-OH-buspirone levels. In contrast to pill count and medication diaries, adherence as measured by riboflavin and 6-OH-buspirone significantly decreased over time. The findings from this study support previous work demonstrating that pill count and patient self-report of medication taking likely overestimate rates of medication adherence, and may become less reliable as the duration of a clinical trial increases. (C) 2015 Elsevier Inc. All rights reserved.