Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative
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DOI：
10.1016/j.bbrc.2009.03.053
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发表时间：
2009-05-01
影响因子：
3.1
通讯作者：
Shimizu, Takahiko
中科院分区：
文献类型：
--
作者：
Murakami, Kazuma;Inagaki, Jun;Shimizu, Takahiko
内在皮肤老化的特征是萎缩和失去弹性。尽管人们已经研究了光老化引起的皮肤肥大，但衰老过程中皮肤萎缩的分子机制仍不清楚。在这里，我们报告说，铜/锌超氧化物歧化酶（CuZn-SOD）缺陷小鼠的皮肤表现出萎缩的形态。这种萎缩伴随着胶原蛋白和弹性纤维的变性，并且皮肤羟脯氨酸在缺陷小鼠中也显著减少。这意味着胶原蛋白和弹性蛋白生物合成的功能障碍参与皮肤变薄的进展。此外，透皮给药可透过膜的维生素C衍生物，完全逆转了突变小鼠的皮肤变薄和胶原蛋白和弹性蛋白的退化。这些表明维生素C衍生物是通过胶原蛋白和弹性蛋白的再生来缓解皮肤老化的强效试剂。CuZn-SOD缺陷小鼠可用于皮肤衰老治疗药物的评价。(C)2009 Elsevier Inc. All rights reserved.
Intrinsic skin ageing is characterized by atrophy and loss of elasticity. Although the skin hypertrophy induced by photoageing has been studied, the molecular mechanisms of skin atrophy during ageing remain unclear. Here, we report that copper/zinc superoxide dismutase (CuZn-SOD)-deficient mice show atrophic morphology in their skin. This atrophy is accompanied by the degeneration of collagen and elastic fibers, and skin hydroxyproline is also significantly reduced in deficient mice. These imply that the dysfunction of collagen and elastin biosynthesis are involved in the progression of skin thinning. Further-More, transdermal administration of a vitamin C derivative which can permeate through the membrane, completely reversed the skin thinning and deterioration of collagen and elastin in the Mutant mice. These indicate that the vitamin C derivative is a powerful agent for alleviating skin ageing through regeneration of collagen and elastin. The CuZn-SOD-deficient mice might be applicable to evaluation of therapeutic medicines against skin ageing. (C) 2009 Elsevier Inc. All rights reserved.