The orbitofrontal cortex, predicted value, and choice
The orbitofrontal cortex, predicted value, and choice
复制标题
DOI：
10.1111/j.1749-6632.2011.06270.x
复制
发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Ostlund, Sean B.
中科院分区：
文献类型：
--
作者：
Balleine, Bernard W.;Leung, Beatrice K.;Ostlund, Sean B.
大量证据表明，目标导向行动之间的选择取决于两个激励过程，这些过程编码目标或结果的奖励值以及基于结果相关刺激的行动的预测值。尽管激励理论通常假设这些过程是由共同的联想机制介导的，但最近的一些研究结果表明它们是可分离的；行动的奖励价值源自对结果本身的圆满体验，而行动的预测价值则基于与结果相关的刺激的存在，从中得出结果可能性的估计。重要的是，啮齿类动物的眶额皮质（OFC）似乎可以调节结果相关刺激对选择的影响。 OFC 损伤破坏了巴甫洛夫刺激对结果特异性巴甫洛夫仪器转移测试中选择的影响。然而，结果相关刺激对选择的影响涉及更大的回路，包括 OFC、腹侧纹状体和杏仁核。然而，这些结构如何相互作用尚未完全理解，这是未来研究的一个重要问题。
Considerable evidence suggests that choice between goal-directed actions depends on two incentive processes encoding the reward value of the goal or outcome and the predicted value of an action based on outcome-related stimuli. Although incentive theories generally assume that these processes are mediated by a common associative mechanism, a number of recent findings suggest that they are dissociable; the reward value of an action is derived from consummatory experience with the outcome itself, whereas the predicted value of an action is based on the presence of outcome-associated stimuli from which estimates of the likelihood of an outcome are derived. Importantly, the orbitofrontal cortex (OFC) in rodents appears to mediate the effect of outcome-related stimuli on choice; OFC lesions disrupt the influence of Pavlovian stimuli on choice in tests of outcome-specific Pavlovian-instrumental transfer. However, the influence of outcome-related stimuli on choice involves a larger circuit including the OFC, the ventral striatum, and the amygdala. How these structures interact, however, is not yet fully understood and is an important question for future research.