Human Genetics Clarifies the Relationship Between Depression and Alzheimer's Disease.
Human Genetics Clarifies the Relationship Between Depression and Alzheimer's Disease.
复制标题
人类遗传学阐明了抑郁症和阿尔茨海默病之间的关系。
DOI：
10.1016/j.biopsych.2022.04.014
复制
发表时间：
2022
影响因子：
10.6
通讯作者：
Yang,Hyun-Sik
中科院分区：
文献类型：
--
作者：
Yang,Hyun-Sik
抑郁症和阿尔茨海默病 (AD) 痴呆是常见的脑部疾病，给患者、护理人员和社会带来巨大痛苦。观察性研究强烈支持抑郁症与 AD 痴呆风险之间的关联 (1, 2)。尽管如此，混杂因素和反向因果关系仍会影响观察性研究 (3)，并且抑郁症和 AD 痴呆之间的因果关系仍不清楚。在最新一期的《生物精神病学》中，Harerimana 等人(4) 利用遗传关联来解决这些局限性，并阐明抑郁症和 AD 痴呆之间的因果关系。
Depression and Alzheimer’s disease (AD) dementia are prevalent brain disorders that lead to an immense patient, caregiver, and societal suffering. Observational studies strongly support the association between depression and the risk of AD dementia (1, 2). Still, confounders and reverse causation can impact observational studies (3), and the causal relationship between depression and AD dementia remains unclear. In the current issue of Biological Psychiatry, Harerimana et al.(4) leverage genetic associations to address these limitations and to clarify the causal relationship between depression and AD dementia.