Impacts of an introduced forest pathogen on the risk of Lyme disease in California.
Impacts of an introduced forest pathogen on the risk of Lyme disease in California.
复制标题
引入的森林病原体对加利福尼亚州莱姆病风险的影响。
DOI：
10.1089/vbz.2011.0783
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Ostfeld,RichardS
中科院分区：
文献类型：
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作者：
Swei,Andrea;Briggs,CherylJ;Lane,RobertS;Ostfeld,RichardS
森林砍伐、气候变化和入侵物种等全球变化有可能通过对生物多样性的影响，极大地改变人畜共患病系统。本研究探讨了入侵病原体的影响，导致突然橡树死亡（SOD）的莱姆病在加州的生态。莱姆病细菌伯氏疏螺旋体（Borrelia burgdorferi）在美国西部由一系列动物宿主维持，包括暗足林鼠（Neotoma fuscipes）和鹿鼠（Peromyscus maniculatus），并由西部黑腿蜱（Ixodes pacificus）传播。其他脊椎动物，如西部栅栏蜥蜴（Sceloporus octagentalis），是重要的蜱宿主，但不是病原体的宿主。先前的研究发现，较高水平的SOD与较高的P丰度相关。maniculatusandS. occupationalisandlowN. fuscipesabundance.在这里，我们模拟这些蜱宿主对莱姆病风险的贡献，并评估SOD对蜱媒感染流行率的潜在影响。通过经验参数化的静态模型与实地和实验室数据蜱主机，我们预测，SOD降低疾病风险的一个重要指标，若虫感染率，导致莱姆病的风险降低在某些沿海林地。SOD对若虫感染流行率影响的直接观察分析支持这些模型结果。这项研究强调了入侵植物病原体对生物多样性、人畜共患病的传播周期以及最终对人类健康的重要直接和间接影响。
Global changes such as deforestation, climate change, and invasive species have the potential to greatly alter zoonotic disease systems through impacts on biodiversity. This study examined the impact of the invasive pathogen that causes sudden oak death (SOD) on the ecology of Lyme disease in California. The Lyme disease bacterium,Borrelia burgdorferi, is maintained in the far western United States by a suite of animal reservoirs including the dusky-footed woodrat (Neotoma fuscipes) and deer mouse (Peromyscus maniculatus), and is transmitted by the western black-legged tick (Ixodes pacificus). Other vertebrates, such as the western fence lizard (Sceloporus occidentalis), are important tick hosts but are not reservoirs of the pathogen. Previous work found that higher levels of SOD are correlated with greater abundance ofP. maniculatusandS. occidentalisand lowerN. fuscipesabundance. Here we model the contribution of these tick hosts to Lyme disease risk and also evaluate the potential impact of SOD on infection prevalence of the tick vector. By empirically parameterizing a static model with field and laboratory data on tick hosts, we predict that SOD reduces an important index of disease risk, nymphal infection prevalence, leading to a reduction in Lyme disease risk in certain coastal woodlands. Direct observational analysis of the impact of SOD on nymphal infection prevalence supports these model results. This study underscores the important direct and indirect impacts of invasive plant pathogens on biodiversity, the transmission cycles of zoonotic diseases, and ultimately human health.