Prediction of Fibrosis Progression Rate in Patients with Chronic Hepatitis C Genotype 4: Role of Cirrhosis Risk Score and Host Factors
Prediction of Fibrosis Progression Rate in Patients with Chronic Hepatitis C Genotype 4: Role of Cirrhosis Risk Score and Host Factors
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DOI：
10.1089/jir.2016.0111
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发表时间：
2017-03-01
影响因子：
2.3
通讯作者：
Abd Elwahab, Mohamed
中科院分区：
文献类型：
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作者：
Besheer, Tarek;El-Bendary, Mahmoud;Abd Elwahab, Mohamed
慢性丙型肝炎(CHC)患者的肝纤维化进展速度是高度可变的，受不同因素的影响。本研究旨在评估基于7个遗传变异(7个单核苷酸多态[SNPs])和宿主因素(年龄和性别)的肝硬变风险评分(CRS)在预测慢性丙型肝炎纤维化进展速度中的作用。对115例患者进行了感染持续时间的测定。每年的纤维化进展率(FPR)计算为纤维化分期与感染持续时间的比值。进行SNP基因分型，并在此基础上确定CRS。在40岁获得感染的患者中，FPR显著高于那些在30-40岁获得感染的患者，那些获得感染在0.8岁的患者预测为肝硬变的高危患者，而CRS值为40岁，男性是较高的FPR的预测因素。
The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) in the prediction of the rate of fibrosis progression in CHC. Duration of infection was determined in 115 patients. The fibrosis progression rate (FPR) per year was calculated as the ratio between fibrosis stage and the duration of infection. SNP genotyping were performed and CRS was determined based on it. FPR was significantly elevated in patients who acquired infection at age >40 years versus those who acquired infection at 30-40 years and those who acquired infection at = 0.8 is predictive of patients with high risk for cirrhosis, and CRS value 40 years, and male sex are predictors of higher FPR.