Aortic stenosis and lipids: does intervention work?
Aortic stenosis and lipids: does intervention work?
复制标题
主动脉瓣狭窄和血脂：干预有效吗？
DOI：
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发表时间：
2010
影响因子：
2.3
通讯作者：
J. Chambers
中科院分区：
文献类型：
--
作者：
A. Wierzbicki;A. Viljoen;J. Chambers
综述目的主动脉瓣狭窄是一种常见疾病，影响越来越多的老年患者，这是与显着增加心血管疾病的发病率和死亡率。组织学和流行病学研究都表明，瓣膜退变的过程可能类似于动脉粥样硬化。本文综述了降脂治疗在其管理中的潜在作用。目前的治疗方法是手术或血管内介入，但人们希望抗动脉粥样硬化治疗可能会导致进展和干预需求的减少。有一些关于降脂治疗的回顾性研究表明，他汀类药物可能有效地减少主动脉瓣狭窄的进展。最近，一系列关于替代进展标志物的侵袭性他汀类药物治疗的试验显示这些措施没有益处。有争议的辛伐他汀-依折麦布和主动脉瓣狭窄（SEAS）终点试验在瓣膜相关和缺血事件的联合终点方面未显示任何获益，但提示该高心血管风险组的心血管事件减少。总结数据清楚地表明，他汀类药物对明确的狭窄性钙化疾病几乎没有影响，但其在疾病过程早期（主动脉瓣硬化）的影响仍有待确定。
Purpose of review Aortic stenosis is a common disorder affecting increasing numbers of elderly patients, which is associated with markedly increased cardiovascular morbidity and mortality. Both histological and epidemiological studies have suggested that the process of valve degeneration may resemble atherosclerosis. This review investigates the potential role of lipid-lowering therapy in its management. Recent findings The current treatment methods are surgical or endovascular intervention but it has been hoped that antiatherosclerotic therapies might result in a reduction in progression and need for intervention. There have been a number of retrospective studies of lipid-lowering therapy, which suggested that statins might be effective in reducing progression of aortic stenosis. Lately a series of trials of aggressive statin therapy on surrogate markers of progression have shown no benefit from these measures. The controversial Simvastatin–Ezetimibe and Aortic Stenosis (SEAS) endpoint trial did not show any benefit on a combined endpoint of valve-related and ischaemic events but hinted at a reduction in cardiovascular events in this high cardiovascular risk group. Summary The data clearly shows statins have little effect in well established stenotic disease with calcification, but their effects earlier in the disease process (aortic valve sclerosis) remain to be determined.
影响因子：
24
作者：
B. Stewart;D. Siscovick;Bonnie K. Lind;J. Gardin;J. Gottdiener;V. Smith;D. Kitzman;C. Otto
通讯作者：
B. Stewart;D. Siscovick;Bonnie K. Lind;J. Gardin;J. Gottdiener;V. Smith;D. Kitzman;C. Otto
影响因子：
37.8
作者：
OBRIEN, KD;KUUSISTO, J;OTTO, CM
通讯作者：
OTTO, CM
影响因子：
8.7
作者：
OBrien, KD;Reichenbach, DD;Otto, CM
通讯作者：
Otto, CM