CIRCADIAN RESPONSES TO LIGHT - THE CALMODULIN CONNECTION
CIRCADIAN RESPONSES TO LIGHT - THE CALMODULIN CONNECTION
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DOI：
10.1016/0304-3940(95)99209-n
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发表时间：
1995-06-09
影响因子：
2.5
通讯作者：
RALPH, MR
中科院分区：
文献类型：
--
作者：
GOLOMBEK, DA;RALPH, MR
KN-62, an inhibitor of CaM kinase II, attenuated phase shifts induced by low intensity light pulses and reduced light-induced phosphorylation of the transcription factor, CREB, in the suprachiasmatic nucleus. The calmodulin inhibitor, W-7, had similar effects: neither drug produced a complete block of photic responses. The results support the hypothesis that circadian responses to light are mediated in part by CaM kinase activity and CREB, and suggest that other signal transduction pathways also take part.
