Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe
Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe
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DOI：
10.2807/1560-7917.es.2020.25.13.2000305
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发表时间：
2020-04-02
期刊：
影响因子：
19
通讯作者：
Lista, Florigio
中科院分区：
文献类型：
--
作者：
Stefanelli, Paola;Faggioni, Giovanni;Lista, Florigio
从两名患者（一名访问罗马的中国游客和一名意大利人）身上获得的SARS-CoV-2的全基因组序列与来自欧洲和其他地方的序列进行了比较。在系统发生树中，意大利患者的序列与来自德国的序列聚在一起，而游客的序列与其他欧洲序列聚在一起。树中的一些额外的欧洲序列分离在包含患者序列的两个聚类之外。这表明SARS-CoV-2在欧洲的多次引入或病毒在流通过程中的进化。
Whole genome sequences of SARS-CoV-2 obtained from two patients, a Chinese tourist visiting Rome and an Italian, were compared with sequences from Europe and elsewhere. In a phylogenetic tree, the Italian patient's sequence clustered with sequences from Germany while the tourist's sequence clustered with other European sequences. Some additional European sequences in the tree segregated outside the two clusters containing the patients' sequences. This suggests multiple SARS-CoV-2 introductions in Europe or virus evolution during circulation.