Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans
Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans
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DOI：
10.1016/j.neuroimage.2010.02.001
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Tobimatsu, Shozo
中科院分区：
文献类型：
--
作者：
Hagiwara, Koichi;Okamoto, Tsuyoshi;Tobimatsu, Shozo
诱导的γ活动在分布式皮质-皮质处理的时间绑定中具有关键作用。为了阐明早期躯体感觉加工过程中的神经同步性，我们利用具有良好时空分辨率的脑磁图（MEG）研究了健康受试者初级和次级躯体感觉皮层（SI和511）之间的功能连接。首先，记录体感诱发的磁场，以确定每个皮层活动的位置。然后，我们分析了锁相值（PLVs）的诱发伽马活动，以评估神经同步的躯体感觉皮层网络。我们还评估了多发性硬化症（MS）患者的PLV，以验证我们的PLV分析在评估区域间功能连接，这往往是受损的MS。PLV的诱导γ活动计算每对非平均MEG信号，代表活动的对侧SI和双边SII区。SI和SII区域之间的PLV的分析表明，显着增加PLV的γ-波段的活动，在正常对照组的早期刺激后阶段开始，而这种增加PLV明显减少MS。PLV分析提供了早期潜伏期的证据，γ-波段的神经元之间的同步SI和SII区域在正常对照组。我们的研究首次证实了人类躯体感觉加工的早期阶段的γ-波段同步性。(C)2010年爱思唯尔公司All rights reserved.
Induced gamma activity has a key role in the temporal binding of distributed cortico-cortical processing. To elucidate the neural synchronization in the early-stage somatosensory processing, we studied the functional connectivity between the primary and secondary somatosensory cortices (SI and 511) in healthy subjects using magnetoencephalography (MEG) with excellent spatiotemporal resolution. First, somatosensory-evoked magnetic fields were recorded to determine the locations of each cortical activity. Then we analyzed the phase-locking values (PLVs) of the induced gamma activity to assess neural synchrony within the somatosensory cortical network. We also assessed PLVs in patients with multiple sclerosis (MS) to validate our PLV analysis in evaluating the inter-areal functional connectivity, which can often be impaired in MS. The PLVs of the induced gamma activity were calculated for each pair of unaveraged MEG signals that represented the activities of the contralateral SI and bilateral SII areas. Analysis of PLVs between the SI and SII areas showed significantly increased PLVs for gamma-band activities, starting at an early post-stimulus stage in normal controls, whereas this increase in PLVs was apparently diminished in MS. The PLV analysis provided evidence for early-latency, gamma-band neuronal synchronization between the SI and SII areas in normal controls. Our study first demonstrates the gamma-band synchrony in the early-stage human somatosensory processing. (C) 2010 Elsevier Inc. All rights reserved.