Fluid intake and the risk of bladder cancer in men
Fluid intake and the risk of bladder cancer in men
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DOI：
10.1056/nejm199905063401803
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发表时间：
1999-05-06
影响因子：
158.5
通讯作者：
Giovannucci, EL
中科院分区：
文献类型：
--
作者：
Michaud, DS;Spiegelman, D;Giovannucci, EL
动物研究表明，排尿频率与尿路上皮中潜在致癌物的水平呈负相关。在人类中，总液体摄入量的增加可以通过稀释尿液代谢物和增加排尿频率来减少致癌物与尿路上皮之间的接触时间。关于液体摄入量与膀胱癌风险之间关系的数据尚无定论。方法：我们在前瞻性健康专业人员随访研究中对47909名参与者进行了为期10年的总液体摄入量与膀胱癌风险之间的关系研究。在随访期间，有252例新诊断的膀胱癌病例，有关总液体摄入量的信息来自食物频率调查问卷上22种饮料的消费频率，1986年，47,909名无癌症的参与者都完成了这一调查问卷。进行logistic回归分析以调整膀胱癌已知和可疑的危险因素。结果每日液体摄入总量与膀胱癌发病风险呈负相关；每日总液体摄入量最高的五分位数（每天摄入100 - 2531英里）与最低的五分位数（每天摄入100 - 2531英里）相比，多变量相对风险为0.51（95%置信区间，0.32 - 0.80）。
Background Studies in animals have shown that the frequency of urination is inversely associated with the level of potential carcinogens in the urothelium. In humans, an increase in total fluid intake may reduce contact time between carcinogens and urothelium by diluting urinary metabolites and increasing the frequency of voiding. The data on fluid intake in relation to the risk of bladder cancer are inconclusive.Methods We examined the relation between total Fluid intake and the risk of bladder cancer over a period of 10 years among 47,909 participants in the prospective Health Professionals Follow-up Study. There were 252 newly diagnosed cases of bladder cancer during the follow-up period, information on total fluid intake was derived from the reported frequency of consumption of the 22 types of beverages on the food-frequency questionnaire, which was completed by each of the 47,909 participants who were free of cancer in 1986. Logistic-regression analyses were performed to adjust for known and suspected risk factors for bladder cancer.Results Total daily fluid intake was inversely associated with the risk of bladder cancer; the multivariate relative risk was 0.51 (95 percent confidence interval, 0.32 to 0.80) for the highest quintile of total daily fluid intake (>2531 mi per day) as compared with the lowest quintile (