The second national tuberculosis prevalence survey in Vietnam
The second national tuberculosis prevalence survey in Vietnam
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DOI：
10.1371/journal.pone.0232142
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发表时间：
2020-04-23
期刊：
影响因子：
3.7
通讯作者：
Nhung Viet Nguyen
中科院分区：
文献类型：
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作者：
Hai Viet Nguyen;Tiemersma, Edine W.;Nhung Viet Nguyen
结核病（TB）仍然是越南发病率和死亡率的重要原因。目前的结核病负担尚不清楚，因为并非所有结核病患者都得到诊断、记录和通知。2017-2018年开展了第二次全国结核病患病率调查，以评估该国目前的结核病负担。在选定群组的住户居住两星期或以上的成年（15岁以上）居民，均获邀参与统计调查。调查参与者在提供书面知情同意书后，通过问卷调查和数字胸部X光检查进行结核病筛查。要求症状筛查阳性和/或胸部X线检查提示TB的个体提供痰液样本，通过Ziehl-Neelsen直接光学显微镜、Xpert MTB/RIF G4、BACTEC MGIT 960液体培养和Lowenstein-Jensen固体培养检测结核分枝杆菌。细菌学确诊的结核病病例由一个专家小组根据标准决策树进行定义。结果在87,207名符合条件的居民中，61,763人（70.8%）参加了调查，4,738人（7.7%）结核病筛查阳性。其中，221名参与者被定义为细菌学确诊的结核病病例。经细菌学证实的成人肺结核患病率估计为322/100，000（95%CI：260-399），男女比例为4.0（2.8-5.8，p
IntroductionTuberculosis (TB) remains a significant cause of morbidity and mortality in Vietnam. The current TB burden is unknown as not all individuals with TB are diagnosed, recorded and notified. The second national TB prevalence survey was conducted in 2017-2018 to assess the current burden of TB disease in the country.MethodEighty-two clusters were selected using a multistage cluster sampling design. Adult (>= 15 years of age) residents having lived for 2 weeks or more in the households of the selected clusters were invited to participate in the survey. The survey participants were screened for TB by a questionnaire and digital chest X-ray after providing written informed consent. Individuals with a positive symptom screen and/or chest X-ray suggestive of TB were asked to provide sputum samples to test for Mycobacterium tuberculosis by Ziehl-Neelsen direct light microscopy, Xpert MTB/RIF G4, BACTEC MGIT960 liquid culture and Lowenstein-Jensen solid culture. Bacteriologically confirmed TB cases were defined by an expert panel following a standard decision tree.ResultOf 87,207 eligible residents, 61,763 (70.8%) participated, and 4,738 (7.7%) screened positive for TB. Among these, 221 participants were defined as bacteriologically confirmed TB cases. The estimated prevalence of bacteriologically confirmed adult pulmonary TB was 322 (95% CI: 260-399) per 100,000, and the male-to-female ratio was 4.0 (2.8-5.8, p