THE ROLE OF BOVINE HIGH-MOLECULAR-WEIGHT (HMW) KININOGEN IN CONTACT-MEDIATED ACTIVATION OF BOVINE FACTOR-XII - INTERACTION OF HMW KININOGEN WITH KAOLIN AND PLASMA PREKALLIKREIN
THE ROLE OF BOVINE HIGH-MOLECULAR-WEIGHT (HMW) KININOGEN IN CONTACT-MEDIATED ACTIVATION OF BOVINE FACTOR-XII - INTERACTION OF HMW KININOGEN WITH KAOLIN AND PLASMA PREKALLIKREIN
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DOI：
10.1093/oxfordjournals.jbchem.a133370
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发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
IWANAGA, S
中科院分区：
文献类型：
--
作者：
IKARI, N;SUGO, T;IWANAGA, S
Bovine high-MW (HMW) kininogen accelerates the kaolin-mediated activation of factor XII in the presence of prekallikrein. Both fragment 1.2 and the L chain regions located in the COOH-terminal half of the kininogen molecule are essential for the activation. The accelerating effect of HMW kininogen, mediated through its adsorption on the kaolin surface through the fragment 1.2 region, and its complex formation with prekallikrein through the L chain region are demonstrated.
