COVID-19 research risks ignoring important host genes due to pre-established research patterns.
COVID-19 research risks ignoring important host genes due to pre-established research patterns.
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DOI：
10.7554/elife.61981
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发表时间：
2020-11-24
期刊：
影响因子：
7.7
通讯作者：
Nunes Amaral LA
中科院分区：
文献类型：
--
作者：
Stoeger T;Nunes Amaral LA
众所周知，对人类基因的研究严重偏向于几十年来已被广泛研究的基因，包括在人类基因组计划的生产阶段之前正在研究的许多基因。这意味着，研究界最常研究的基因对人类生理和疾病的重要性往往只比随机选择的基因稍微高一点。基于对10，395篇关于SARS-CoV-2的研究出版物的分析，这些出版物至少提到了一个人类基因，我们在这里报告说，截至2020年10月中旬的COVID-19文献遵循类似的模式。这意味着大量的宿主基因，已经牵连到SARS冠状病毒-2感染的四个全基因组研究仍然没有研究。虽然无法量化这种忽视的后果，但这些后果可能很严重。
It is known that research into human genes is heavily skewed towards genes that have been widely studied for decades, including many genes that were being studied before the productive phase of the Human Genome Project. This means that the genes most frequently investigated by the research community tend to be only marginally more important to human physiology and disease than a random selection of genes. Based on an analysis of 10,395 research publications about SARS-CoV-2 that mention at least one human gene, we report here that the COVID-19 literature up to mid-October 2020 follows a similar pattern. This means that a large number of host genes that have been implicated in SARS-CoV-2 infection by four genome-wide studies remain unstudied. While quantifying the consequences of this neglect is not possible, they could be significant.