Decellularized cartilage as a prospective scaffold for cartilage repair
Decellularized cartilage as a prospective scaffold for cartilage repair
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脱细胞软骨作为软骨修复的未来支架
DOI：
10.1016/j.msec.2019.04.002
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Chen Pengfei
中科院分区：
文献类型：
--
作者：
Xia Chen;Mei Sheng;Gu Chenhui;Zheng Lin;Fang Chen;Shi Yiling;Wu Kaiwei;Lu Tongtong;Jin Yongming;Lin Xianfeng;Chen Pengfei
Articular cartilage lacks self-healing capacity, and there is no effective therapy facilitating cartilage repair. Osteoarthritis (OA) due to cartilage defects represents large and increasing healthcare burdens worldwide. Nowadays, the generation of scaffolds to preserve bioactive factors and the biophysical environment has received increasing attention. Furthermore, improved decellularization technology has provided novel insights into OA treatment. This review provides a comparative account of different cartilage defect therapies. Furthermore, some recent effective decellularization protocols have been discussed. In particular, this review focuses on the decellularization ratio of each protocol. Moreover, these protocols were compared particularly on the basis of immunogenicity and mechanical functionality. Further, various recellularization methods have been enlisted and the reparative capacity of decellularized cartilage scaffolds is evaluated herein. The advantages and limitations of different recellularization processes have been described herein. This provides a basis for the generation of decellularized cartilage scaffolds, thereby potentially promoting the possibility of decellularization as a clinical therapeutic target.
