New anti-inflammatory flavonoids from Cadaba glandulosa Forssk
New anti-inflammatory flavonoids from Cadaba glandulosa Forssk
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DOI：
10.1007/s12272-013-0305-1
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发表时间：
2014-04-01
影响因子：
6.7
通讯作者：
Ross, Samir A.
中科院分区：
文献类型：
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作者：
Mohamed, Gamal A.;Ibrahim, Sabrin R. M.;Ross, Samir A.
三个新的黄酮类化合物;山奈酚-4 ′-苯氧基-3，3 ′，5 ′-三甲基醚（3），鼠李柠檬素-4 ′-（4-羟基-3-甲氧基）苯氧基-3-甲基醚（4），和鼠李柠檬素-3-O-新橙皮苷-4 ′-O-鼠李糖苷（6），沿着三个已知化合物：4-甲氧基-苯甲醛（1），山奈酚-3-甲基醚（2），和水苏碱（5）从Cadaba glandulosa Forssk的地上部分分离得到。通过物理、化学和光谱方法，以及与文献数据的比较，确定了它们的化学结构。对分离得到的化合物进行了抗氧化和抗炎活性的测定。化合物2-4和6表现出与吲哚美辛相当的有效抗炎活性和中等的抗氧化活性。
Three new flavonoids; kaempferol-4'-phenoxy-3,3',5'-trimethylether (3), rhamnocitrin-4'-(4-hydroxy-3-methoxy)phenoxy-3-methyl ether (4), and rhamnocitrin-3-O-neohesperoside-4'-O-rhamnoside (6), along with three known compounds; 4-methoxy-benzyldehyde (1), kaempferol-3-methylether (2), and stachydrine (5) were isolated from the aerial parts of Cadaba glandulosa Forssk. Their chemical structures were established by physical, chemical, and spectral methods, as well as comparison with literature data. The antioxidant and anti-inflammatory activities of the isolated compounds were determined. Compounds 2-4, and 6 exhibited potent anti-inflammatory activity comparable with indomethacin and moderate antioxidant activity.