VASCULAR AND CELLULAR-CHANGES IN THE DECIDUALIZED ENDOMETRIUM OF THE OVARIECTOMIZED MOUSE FOLLOWING CESSATION OF HORMONE-TREATMENT - A POSSIBLE MODEL FOR MENSTRUATION
VASCULAR AND CELLULAR-CHANGES IN THE DECIDUALIZED ENDOMETRIUM OF THE OVARIECTOMIZED MOUSE FOLLOWING CESSATION OF HORMONE-TREATMENT - A POSSIBLE MODEL FOR MENSTRUATION
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DOI：
10.1677/joe.0.1000295
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发表时间：
1984-01-01
影响因子：
4
通讯作者：
POPE, M
中科院分区：
文献类型：
--
作者：
FINN, CA;POPE, M
去卵巢小鼠子宫腔内注射花生油，雌孕激素诱导小鼠蜕膜形成。然后停止激素注射，并在最后一次注射孕酮后31至84小时间隔检查子宫。31h和35h，蜕膜间质反应正常。在45~79h，间质经历了一系列的变化，首先是扩张的血管充血，红血球肿胀，然后是血管壁破裂和血液渗出。同时，蜕膜细胞出现典型的凋亡改变，并有白细胞的侵袭。外环的间质没有参与退化过程；最终，血细胞的中心核心和退化的蜕膜细胞分离并脱落到管腔内。以完全相同的方式处理的动物，但没有蜕膜刺激，在基质中没有表现出这样的变化。显然，子宫内膜的变化与月经相似，并支持月经发生必须分化间质才能植入的建议。这在女性的周期中会发生，但在非灵长类动物中不会发生，除非对子宫施加蜕膜刺激。
Ovariectomized mice were prepared for decidualization with estrogen and progesterone, and arachis oil injected into the uterine lumen. Hormone injections were then stopped and uteri examined at intervals between 31 and 84 h after the last progestrone injection. At 31 and 35 h the stroma showed a normal decidual reaction. Between 45 and 79 h the stroma underwent a series of changes which started with the congestion of dilated blood vessels with swollen erythrocytes followed by breakdown of the vessel walls and extravasation of blood. At the same time the decidual cells showed typical apoptotic changes and there was invasion by leukocytes. An outer ring of stroma did not take part in the degenerative process; eventually a central core of blood cells and degenerating decidual cells became detached and was shed into the lumen. Animals treated in exactly the same way but with the omission of the decidual stimulus did not show such changes in the stroma. Apparently the changes in the endometrium resemble those of menstruation and support the suggestion that for menstruation to occur the stroma must be differentiated for implantation. This occurs during the cycle in women but does not occur in non-primates unless a decidual stimulus is applied to the uterus.