Microneedle fabrication methods and applications
Microneedle fabrication methods and applications
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DOI：
10.1557/s43579-023-00355-0
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发表时间：
2023-03-24
影响因子：
1.9
通讯作者：
Narayan, Roger
中科院分区：
文献类型：
--
作者：
Machekposhti, Sina Azizi;Khanna, Sumeer;Narayan, Roger
微针是微尺度的针形装置，其已经引起了生物医学工程界的关注，用于经皮药物递送、传感和疫苗递送。这些装置在皮肤穿透过程中不会造成明显的不适。最近已经使用微针来检测组织液中的生理相关分子以用于健康监测。在这篇综述中，与微针加工相关的技术挑战被认为是。描述了与微针穿透皮肤相关的机械要求。本文介绍了聚合物、生物陶瓷和天然材料在微针制造中的应用。描述了微针在生物传感、药物递送和疫苗递送中的最新用途。
Microneedles are microscale needle-shaped devices that have attracted attention from the biomedical engineering community for transdermal drug delivery, sensing, and vaccine delivery. These devices do not inflict significant discomfort during skin penetration. Microneedles have recently been used to detect physiologically relevant molecules in interstitial fluid for health monitoring. In this review, technical challenges associated with microneedle processing are considered. The mechanical requirements associated with microneedle penetration of the skin are described. The use of polymers, bioceramics, and natural materials in microneedle fabrication is described. Recent uses of microneedles in biosensing, drug delivery, and vaccine delivery are described.