Mirror neurons precede non-mirror neurons during action execution.
Mirror neurons precede non-mirror neurons during action execution.
复制标题
在动作执行过程中，镜像神经元先于非镜像神经元。
DOI：
10.1152/jn.00653.2019
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发表时间：
2019
影响因子：
2.5
通讯作者：
Schieber,MarcH
中科院分区：
文献类型：
--
作者：
Mazurek,KevinA;Schieber,MarcH
镜像神经元被认为代表了一个人理解他人行为的能力，当一个人执行或观察另一个人执行一个动作时，镜像神经元会放电。研究通常集中在动作观察期间的镜像神经元活动，检查动作执行期间的活动主要是为了验证镜像神经元参与运动行为。因此，人们对镜像神经元在动作执行过程中的确切作用知之甚少。在本研究中，我们发现在执行伸手-抓握-操作动作时，镜像神经元的活动一般先于非镜像神经元的活动。不仅任务相关的调制发生在镜像神经元的早期，但隐马尔可夫模型检测到的状态转换也发生在镜像神经元群体的早期。我们的研究结果表明，镜像神经元可能处于动作执行的最前沿。新&值得注意的是，镜像神经元通常被认为是理解他人动作的神经基质，但镜像神经元在动作执行过程中也是活跃的，当其他非镜像神经元也活跃时。检查活动的时间在执行过程中的自然达到把握操纵任务，我们发现，镜像神经元的活动之前，非镜像神经元在单位和人口水平。因此，镜像神经元可能处于动作执行的前沿。
Mirror neurons are thought to represent an individual’s ability to understand the actions of others by discharging as one individual performs or observes another individual performing an action. Studies typically have focused on mirror neuron activity during action observation, examining activity during action execution primarily to validate mirror neuron involvement in the motor act. As a result, little is known about the precise role of mirror neurons during action execution. In this study, during execution of reach-grasp-manipulate movements, we found activity of mirror neurons generally preceded that of non-mirror neurons. Not only did the onset of task-related modulation occur earlier in mirror neurons, but state transitions detected by hidden Markov models also occurred earlier in mirror neuron populations. Our findings suggest that mirror neurons may be at the forefront of action execution.NEW & NOTEWORTHYMirror neurons commonly are thought to provide a neural substrate for understanding the actions of others, but mirror neurons also are active during action execution, when additional, non-mirror neurons are active as well. Examining the timing of activity during execution of a naturalistic reach-grasp-manipulate task, we found that mirror neuron activity precedes that of non-mirror neurons at both the unit and the population level. Thus mirror neurons may be at the leading edge of action execution.