The DRD4 VNTR polymorphism moderates craving after alcohol consumption
The DRD4 VNTR polymorphism moderates craving after alcohol consumption
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DOI：
10.1037//0278-6133.21.2.139
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发表时间：
2002-03-01
影响因子：
4.2
通讯作者：
Swift, RM
中科院分区：
文献类型：
--
作者：
Hutchison, KE;McGeary, J;Swift, RM
最近的研究表明，中脑边缘多巴胺神经传递的改变对酒精渴望的发展和表达至关重要。由于D-4多巴胺受体基因可变数串联重复序列（DRD4 VNTR）多态性被认为表达了多巴胺受体的功能差异，因此本研究测试了这种多态性是否会影响酒精启动剂量对渴望的影响。参与者喝了3杯酒精饮料或3杯对照饮料，并在每次饮酒后完成对渴望程度的测量。7个（或更长）重复等位基因纯合或杂合的参与者被归类为DRD4 L，而其他参与者被归类为DRD4 s。结果表明，与对照饮料相比，DRD4 L参与者在饮酒后表现出明显更高的渴望。
Recent research has suggested that alterations in mesolimbic dopamine neurotransmission are central to the development and expression of craving for alcohol. Because the D-4 dopamine receptor gene, variable numbers of tandem repeats (DRD4 VNTR) polymorphism putatively expresses functional differences in dopamine receptors, the present study tested whether this polymorphism influences the effects of a priming dose of alcohol on craving. Participants consumed 3 alcoholic drinks or 3 control drinks and completed measures of craving after each drink. Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele were classified as DRD4 L, whereas the other participants were classified as DRD4 S. Results suggested that DRD4 L participants demonstrated significantly higher craving after consumption of alcohol as compared with the control beverage.