Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications.
Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications.
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DOI：
10.1038/ncomms9003
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发表时间：
2015-08-06
影响因子：
16.6
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Liu F;He X;Chen H;Zhang J;Zhang H;Wang Z
超小的流体动力学直径是在合理的时间尺度内从体内肾清除纳米颗粒的关键因素。然而，将诊断和治疗成分整合到单个超小纳米颗粒中仍然具有挑战性。在这项研究中，pH激活的纳米点（称为Fe-CPNDs）组成的配位聚合物的合成通过一个简单的和可扩展的方法的基础上的Fe 3+，没食子酸和聚（乙烯基吡咯烷酮）之间的配位反应在环境条件下。Fe-CPND具有超小（5.3 nm）的流体动力学直径和电中性表面。Fe-CPND还表现出pH可激活的磁共振成像对比度和出色的光热性能。Fe-CPNDs的特征大大增加了肿瘤成像的灵敏度，并促进了体内动物模型注射后的肾清除。磁共振成像引导的光热疗法使用Fe-CPND完全抑制肿瘤生长。这些发现表明，Fe-CPND构成了一类新的肾可清除的纳米药物，用于光热治疗和分子成像。 配位聚合物由于其结构性质易于控制，是一种很有前途的药物纳米载体材料。在这里，Wang等人制备了将癌症成像和治疗功能与有益的肾清除相结合的配位纳米点。
An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among Fe3+, gallic acid and poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. The Fe-CPNDs also exhibited pH-activatable magnetic resonance imaging contrast and outstanding photothermal performance. The features of Fe-CPNDs greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. Magnetic resonance imaging-guided photothermal therapy using Fe-CPNDs completely suppressed tumour growth. These findings demonstrate that Fe-CPNDs constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging. Coordination polymers are promising drug delivery nanomaterials as their structural properties can be easily controlled. Here, Wang et al. prepare coordination nanodots that integrate cancer imaging and therapeutic functions with beneficial renal clearance.