Facile Multicomponent Synthesis of Novel 2,3-Dihydropyran Derivatives under Solvent-Free Conditions
Facile Multicomponent Synthesis of Novel 2,3-Dihydropyran Derivatives under Solvent-Free Conditions
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无溶剂条件下轻松多组分合成新型 2,3-二氢吡喃衍生物
DOI：
10.1055/s-0030-1258417
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发表时间：
2011-02
影响因子：
2.6
通讯作者：
Liu, Bo-Kai
中科院分区：
文献类型：
--
作者：
Li, Li;Lin, Xian-Fu;Wu, Qi;Liu, Bo-Kai
在无溶剂条件下，以二乙酸乙二胺（EDDA）为催化剂，以醛、1,3-二羰基衍生物和乙烯醚为原料，通过一锅三组分反应合成了一系列新的取代的2,3-二氢吡喃衍生物。这种新的、简单的、高效的、无溶剂的、一锅法从简单的底物开始直接得到取代的2,3-二氢吡喃支架。
A series of new, substituted 2,3-dihydropyran derivatives were synthesized by one-pot, three-component reactions of aldehydes, 1,3-dicarbonyl derivatives, and vinyl ethers catalyzed by ethylenediamine diacetate (EDDA) under solvent-free conditions. This new, simple, and efficient, solvent-free, one-pot approach to the substituted 2,3-dihydropyran scaffold starting from simple substrates was found to take place directly.