Serum albumin is associated with skeletal muscle in elderly men and women
Serum albumin is associated with skeletal muscle in elderly men and women
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DOI：
10.1093/ajcn/64.4.552
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发表时间：
1996-10-01
影响因子：
7.1
通讯作者：
Garry, PJ
中科院分区：
文献类型：
--
作者：
Baumgartner, RN;Koehler, KM;Garry, PJ
血清白蛋白浓度随着年龄和数值的降低而降低；38g/L与老年人的发病率、死亡率和残疾增加相关。目前尚不清楚这种下降在多大程度上独立于新陈代谢、饮食摄入量、体力活动、发病率或身体成分的变化。我们研究了275名60-95岁的男性和女性的血清白蛋白与年龄、蛋白质和能量摄入量、体力活动、发病率和肌肉质量的关系。日常饮食摄入量和体力活动通过问卷调查进行量化。发病率通过病史、问卷和检查来确定。采用双能X线骨密度仪测定肌肉质量。在多变量分析中，在控制了男性和女性的年龄、蛋白质摄入量、体力活动和共病后，血清白蛋白与肌肉质量显著相关。这项研究表明，随着年龄的增长，血清白蛋白浓度的降低与老年人的肌肉萎缩(骨质疏松症)有关。这种联系与其他可能影响肌肉质量和白蛋白浓度的因素无关。我们认为，在老年人中观察到的低血清白蛋白浓度增加的残疾风险实际上可能反映了与骨质疏松症有关。
Serum albumin concentrations decrease with age and values < 38 g/L are associated with increased morbidity mortality, and disability in the elderly. It is not clear to what extent the decreases are associated independently with changes in metabolism, dietary intake, physical activity, morbidity, or body composition. We examined associations of serum albumin with age, protein and energy intakes, physical activity, morbidity, and muscle mass in 275 men and women aged 60-95 y. Serum albumin was measured with the bromcresol green procedure. Usual dietary intake and physical activity were quantified through questionnaires. Morbidity was ascertained from medical history, questionnaire, and examination. Muscle mass was estimated from dual-energy X-ray absorptiometry. In multivariate analyses, serum albumin was associated significantly with muscle mass after age, protein intake, physical activity, and comorbidity were controlled for in men and women. This study suggests that decreases with age in serum albumin concentrations are associated with muscle loss (sarcopenia) in the elderly. This association is independent of other factors that may affect muscle mass and albumin concentration. We suggest that the increased risk of disability with low serum albumin concentrations observed in the elderly may actually reflect an association with sarcopenia.