Biomineralized Iron Oxide–Polydopamine Hybrid Nanodots for Contrast-Enhanced T1-Weighted Magnetic Resonance Imaging and Photothermal Tumor Ablation
Biomineralized Iron Oxide–Polydopamine Hybrid Nanodots for Contrast-Enhanced T1-Weighted Magnetic Resonance Imaging and Photothermal Tumor Ablation
复制标题
生物矿化氧化铁与聚多巴胺混合纳米点用于增强 T1 加权磁共振成像和光热肿瘤消融
DOI：
10.1039/d1tb00032b
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发表时间：
2021
影响因子：
7
通讯作者：
Ke Hengte
中科院分区：
文献类型：
--
作者：
Wang Ze'ai;Wang Yanfeng;Wang Yuan;Wei Chaogang;Deng Yibin;Chen Huabing;Shen Junkang;Ke Hengte
氧化铁纳米颗粒(IO NPs)由于其固有的磁性和生物可降解性，以及较长的血半衰期和低毒性，已成为对比增强磁共振(MR)成像分子成像探针的研究重点。作为T2加权磁共振造影剂，IO纳米粒子具有很高的敏感性，可以产生干扰诊断的远距离磁场，因此人们进行了大量的研究。因此，具有强大的T1弛豫性能的IO纳米粒子的开发可能有助于为临床应用的Gd螯合物提供一种替代方案。本论文以白蛋白为纳米反应器，构建了生物矿化氧化铁-多巴胺杂化纳米点(IO/PDA-NDS)，以诱导纳米沉淀和聚合，促进T1加权对比度增强和光热治疗能力。IO/PDA-NDS中的IO纳米团簇的R1弛豫度为5.79mM−1 S−1，R2/R1值为1.71，说明氧化铁基T1造影剂是一种较好的造影剂。杂化纳米点具有较高的光热转换系数和肿瘤靶向作用，可获得完全的肿瘤消融效果。生物矿化方法为肿瘤诊疗一体化提供了一条很有前途的途径，以实现有效的肿瘤治疗。
Iron oxide nanoparticles (IO NPs) have become the focus of molecular imaging probes for contrast enhanced magnetic resonance (MR) imaging due to their intrinsic magnetic and biodegradable properties, as well as long blood half-lives and low toxicity. Massive efforts have been made to explore the IO NPs as T2-weighted MR contrast agents, which have high susceptibility to induce a long-range magnetic field that interferes with diagnosis. Thus, the development of IO NPs with potent T1 relaxivity might help in providing an alternative for clinically applied gadolinium chelates. Herein, biomineralized iron oxide–polydopamine hybrid nanodots (IO/PDA-NDs) have been constructed using albumin as the nanoreactors to induce nanoprecipitation and polymerization simultaneously, facilitating T1-weighted contrast-enhancement as well as photothermal therapeutic capability. The IO nanoclusters in IO/PDA-NDs have an r1 relaxivity of 5.79 mM−1 s−1 with a relatively low r2/r1 ratio of 1.71, demonstrating the preferable iron oxide based T1 contrast agents. The high photothermal conversion coefficient and tumor targeting effect of the hybrid nanodots could result in complete tumor ablation efficacy. The biomineralization method provides a promising approach for the integration of tumor diagnosis and treatment to achieve efficient cancer theranostics.