Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex
Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex
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DOI：
10.1016/j.tetlet.2007.05.003
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发表时间：
2007-06-25
影响因子：
1.8
通讯作者：
Kobayashi, Motomasa
中科院分区：
文献类型：
--
作者：
Aoki, Shunji;Watanabe, Yasuo;Kobayashi, Motomasa
Three novel anti-angiogenic steroidal alkaloids, cortistatins J (1), K (2), L (3), have been isolated from the Indonesian marine sponge Corticium simplex. The chemical structures of cortistatins J (1), K (2), and L (3) were determined by 2D-NMR analysis to be unique abeo-9(10-19)-androstane-type steroidal alkaloids having isoquinoline unit instead of the side chain part, respectively. Cortistatin J (1) showed cytostatic anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) at 8 nM, in which the selective index was 300-1000-fold in comparison with other cell lines. (c) 2007 Elsevier Ltd. All rights reserved.
