Acute encephalopathy in an immunocompromised boy with astrovirus-MLB1 infection detected by next generation sequencing
Acute encephalopathy in an immunocompromised boy with astrovirus-MLB1 infection detected by next generation sequencing
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DOI：
10.1016/j.jcv.2016.03.010
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发表时间：
2016-05-01
影响因子：
8.8
通讯作者：
Tanaka-Taya, Keiko
中科院分区：
文献类型：
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作者：
Sato, Masanori;Kuroda, Makoto;Tanaka-Taya, Keiko
我们报告一例免疫缺陷的4岁男童的急性脑病，可能与人类星形病毒MLB1感染有关。通过下一代测序，在他的粪便、血清、脑脊液、尿液和咽拭子中鉴定出星状病毒MLB1基因组。我们提出的更多证据表明，人类星状病毒是重要的感染性病原体，无论其分支如何，在免疫受损的宿主中涉及中枢神经系统。(C)2016爱思唯尔B.V.保留所有权利。
We report a case of an immunodeficient 4-year-old boy with acute encephalopathy possibly related to human astrovirus-MLB1 infection. The astrovirus-MLB1 genome was identified in his stool, serum, cerebrospinal fluid, urine, and throat swabs by next generation sequencing. We present additional evidence showing human astroviruses are important infectious agents, regardless of their clades, involving the central nervous system in immunocompromised hosts. (C) 2016 Elsevier B.V. All rights reserved.