Contributions of area Te2 to rat recognition memory
Contributions of area Te2 to rat recognition memory
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DOI：
10.1101/lm.2167511
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发表时间：
2011-07-01
影响因子：
2
通讯作者：
Brown, Malcolm Watson
中科院分区：
文献类型：
--
作者：
Ho, Jonathan Weng-Thim;Narduzzo, Katherine Elizabeth;Brown, Malcolm Watson
本实验采用烧蚀和局部脑内灌注的方法，研究了大鼠颞叶联合皮层（Te 2区）在物体再认记忆中的作用，并与邻近的嗅周皮层（PRH）进行了比较。Te 2的双侧损伤损害识别记忆，通过在延迟>= 20分钟时优先探索新的而不是熟悉的物体来测量，但在延迟5分钟后则没有。局部输注双侧Te 2（1）CNQX阻断AMPA/红藻氨酸受体或（2）利多卡因阻断轴突传递或（3）AP 5，一种NMDA受体拮抗剂，在24小时后，但不是20分钟后，识别记忆受损。在PRH中，所有这些操作在20分钟以及24小时延迟后损害识别记忆。UBP 302，一种GluK 1红藻氨酸受体拮抗剂，在24小时但不是20分钟的延迟后损害识别记忆，与其在PRH中的作用形成对比，在PRH中它只损害短期（20分钟）识别记忆。与PRH相反，毒蕈碱受体拮抗剂东莨菪碱的输注没有效果。Te 2损伤不能轻易归因于知觉缺陷。因此，Te 2是必不可少的对象识别记忆在延迟>5或20分钟。因此，在长时间的延迟两个区域Te 2和PRH是必要的对象识别记忆。
Ablations and local intracerebral infusions were used to determine the role of rat temporal association cortex (area Te2) in object recognition memory, so that this role might be compared with that of the adjacent perirhinal cortex (PRH). Bilateral lesions of Te2 impaired recognition memory measured by preferential exploration of a novel rather than a familiar object at delays >= 20 min but not after a 5-min delay. Local infusion bilaterally into Te2 of (1) CNQX to block AMPA/kainate receptors or (2) lidocaine to block axonal transmission or (3) AP5, an NMDA receptor antagonist, impaired recognition memory after a 24-h but not a 20-min delay. In PRH all these manipulations impair recognition memory after a 20-min as well as a 24-h delay. UBP302, a GluK1 kainate receptor antagonist, impaired recognition memory after a 24-h but not a 20-min delay, contrasting with its action in PRH where it impairs only shorter-term (20 min) recognition memory. Also in contrast to PRH, infusion of the muscarinic receptor antagonist scopolamine was without effect. The Te2 impairments could not readily be ascribed to perceptual deficits. Hence, Te2 is essential for object recognition memory at delays >5 or 20 min. Thus, at long delays both area Te2 and PRH are necessary for object recognition memory.