Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic.
Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic.
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DOI：
10.1080/08927014.2013.773317
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发表时间：
2013
期刊：
影响因子：
2.7
通讯作者：
Copié V
中科院分区：
文献类型：
--
作者：
Ammons MC;Copié V
医学相关的生物膜已经获得了显着的兴趣，部分原因是肥胖症的流行和发达国家人口老龄化。慢性伤口的相关合并症，如压疮、下肢静脉溃疡和糖尿病足伤口，仍然不符合目前可用的治疗方法。伤口慢性化的发展主要是由于生物负载（特别是细菌生物膜）的存在而无法完成伤口愈合过程。显然需要专门针对生物膜的新疗法。乳铁蛋白是先天免疫系统的多面分子，主要存在于牛奶中。虽然需要进一步研究以阐明作用机制，但乳铁蛋白及其衍生物的体外分析已经证明，这些复杂分子在结构和功能上非常适合于解决细菌生物膜的异质性。此外，乳铁蛋白及其衍生物的使用已被证明在临床上很有前途。
Medically relevant biofilms have gained a significant level of interest, in part because of the epidemic rise in obesity and an aging population in the developed world. The associated comorbidities of chronic wounds such as pressure ulcers, venous leg ulcers, and diabetic foot wounds remain recalcitrant to the therapies available currently. Development of chronicity in the wound is due primarily to an inability to complete the wound healing process owing to the presence of a bioburden, specifically bacterial biofilms. New therapies are clearly needed which specifically target biofilms. Lactoferrin is a multifaceted molecule of the innate immune system found primarily in milk. While further investigation is warranted to elucidate mechanisms of action, in vitro analyses of lactoferrin and its derivatives have demonstrated that these complex molecules are structurally and functionally well suited to address the heterogeneity of bacterial biofilms. In addition, use of lactoferrin and its derivatives has proven promising in the clinic.
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影响因子：
5.4
作者：
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通讯作者：
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