Comparison of methadone and high dosage buprenorphine users in French care centres
Comparison of methadone and high dosage buprenorphine users in French care centres
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DOI：
10.1046/j.1360-0443.2001.961014337.x
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发表时间：
2001-10-01
期刊：
影响因子：
6
通讯作者：
San Marco, JL
中科院分区：
文献类型：
--
作者：
Barrau, K;Thirion, X;San Marco, JL
目标。在法国，阿片剂使用者维持方案比其他国家通过得晚。可提供两种维持治疗：美沙酮仅在专业中心提供，而高剂量丁丙诺啡可由所有全科医生和专业中心开处方。这项研究的目的是比较在专门中心接受治疗的两个群体的社会人口概况、做法和药物消费模式。方法。Oppidum方案（观察非法药物和滥用精神药物情况）是一项多中心调查，每年对法国各地专门护理中心的药物依赖对象进行调查。通过前一周的社会人口变量和药物使用问卷收集数据。结果。1998年10月，46个中心参加了调查。美沙酮组（n = 424）年龄较大，经济状况较好；16%的人经常使用可卡因。HD丁丙诺啡组（n = 616）消耗了更多的海洛因（12%对8%），并且有更多的滥用行为，如静脉注射、非法获取或不定期使用。这些行为在“外出用药”的患者或从全科医生处获得药物的患者中更为常见。结论。我们的研究结果表明，美沙酮和丁丙诺啡的消费模式在几个方面有所不同：同时使用合法或非法的精神活性物质，给药途径和非法获取。他们还指出，维持治疗使用者的行为与其说取决于维持药物（美沙酮或大剂量丁丙诺啡）的性质，不如说取决于给药和监测实践的性质。
Aims. In France, maintenance programmes for opiate users were adopted later than in other countries. Two maintenance treatments are available: methadone is only delivered in specialized centres while high dosage (HD) buprenorphine can be prescribed by all general practitioners and in specialized centres. The aim of this study was to compare the socio-demographic profiles, the practices and drug consumption patterns of the two groups attending specialized centres. Methodology. The Oppidum Programme (observation of illegal drugs and misuse of psychotropic medications), a multi-centric survey, surveys drug-dependent subjects attending specialized care centres throughout France annually. Data were collected by questionnaire on socio-demographic variables and drug use during the preceding week. Results. During October 1998, 46 centres took part in the survey. The methadone group (n = 424) was older, with a better economic situation; 16% used cocaine regularly. The HD buprenorphine group (n = 616) consumed more heroin (12% vs. 8%) and engaged in more misuse, such as intravenous use, illicit acquisitions or irregular consumption. These practices were more frequent for patients consuming the drug "outwith protocol" or for patients obtaining the drug from a general practitioner. Conclusion. Our results suggest that patterns of consumption of methadone and buprenorphine are different in several respects: concomitant use of licit or illicit psychoactive substances, route of administration, and illegal acquisition. They also suggest that the behaviours of maintenance treatment users depend less on the nature of the maintenance drug (methadone or high dosage buprenorphine), than the nature of the delivery and monitoring practices.