Field performance of engineered male mosquitoes
Field performance of engineered male mosquitoes
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DOI：
10.1038/nbt.2019
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发表时间：
2011-11-01
影响因子：
46.9
通讯作者：
Alphey, Luke
中科院分区：
文献类型：
--
作者：
Harris, Angela F.;Nimmo, Derric;Alphey, Luke
登革热是医学上最重要的节肢动物传播的病毒性疾病，全球每年报告5000万至1亿例病例（1）。由于没有获得许可的登革热疫苗或专门的治疗方法，控制该疾病的最有希望的策略涉及针对主要蚊子载体埃及伊蚊。然而，目前的方法是不够的。已经提出了涉及基因工程蚊子的各种方法（2-4），包括释放转基因不育雄性（5-10）。然而，实验室饲养的工程雄性蚊子在寻找和与野生雌性交配方面与野生雄性蚊子有效竞争的能力（这对这些策略的成功至关重要）尚未得到测试。我们报告了第一次涉及一种基因改造蚊子的野外试验的数据。我们证明了转基因雄性蚊子，在10公顷的范围内释放4周，成功地与野生雌性蚊子交配并使它们的卵受精。这些发现表明，该技术通过抑制A.埃及人。
Dengue is the most medically important arthropod-borne viral disease, with 50-100 million cases reported annually worldwide(1). As no licensed vaccine or dedicated therapy exists for dengue, the most promising strategies to control the disease involve targeting the predominant mosquito vector, Aedes aegypti. However, the current methods to do this are inadequate. Various approaches involving genetically engineered mosquitoes have been proposed(2-4), including the release of transgenic sterile males(5-10). However, the ability of laboratory-reared, engineered male mosquitoes to effectively compete with wild males in terms of finding and mating with wild females, which is critical to the success of these strategies, has remained untested. We report data from the first open-field trial involving a strain of engineered mosquito. We demonstrated that genetically modified male mosquitoes, released across 10 hectares for a 4-week period, mated successfully with wild females and fertilized their eggs. These findings suggest the feasibility of this technology to control dengue by suppressing field populations of A. aegypti.