Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population
Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population
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DOI：
10.1007/s10522-009-9251-1
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发表时间：
2010-06-01
期刊：
影响因子：
4.5
通讯作者：
Mocchegiani, Eugenio
中科院分区：
文献类型：
--
作者：
Malavolta, Marco;Giacconi, Robertina;Mocchegiani, Eugenio
据报道，血浆铜和锌水平与最重要的年龄相关疾病的发病率之间存在关联。以前提出的使用血浆铜/锌作为全因死亡率预测指标的方法是从老年和高龄受试者代表性不足的人群中得出的。这篇文章的目的是评估血浆铜/锌作为老年人有害炎症或营养变化的敏感生物标志物的有用性，以及其在意大利功能独立的老年队列中作为全因死亡率预测因子的递增预后作用。对498例老年人血浆铜锌比值与炎症指标(CRP、ESR、IL-6)和营养指标(白蛋白、BMI)的相关性进行了研究。血液样本取自164名20至60岁的健康志愿者对照组。对218名70岁以上的老年人进行了一项3.5年的前瞻性随访研究，研究对象为年龄相关疾病的死亡率。血浆铜/锌比值与所有研究的炎症标志物以及血清白蛋白相关，并预测70岁以上受试者3.5年的死亡率。血浆铜锌比值女性高于男性，且随年龄增长而升高。稳定型心脑血管疾病(CVD)患者血浆铜/锌比值明显高于非心血管病患者，主要是由于血浆铜升高所致。然而，大多数与年龄相关的铜/锌的变化是由于血浆锌的进行性下降所致。铜/锌比值可能被认为是一个重要的临床炎症-营养生物标志物，也是70岁以上老年人全因死亡率的重要预测因子。
Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose of this paper is to estimate the usefulness of plasma Cu/Zn as a sensitive biomarker of harmful inflammatory or nutritional changes in the elderly and its incremental prognostic utility as a predictor of all-cause mortality in a functionally independent elderly Italian cohort. The association between plasma Cu/Zn and inflammatory (CRP, ESR, IL-6) or nutritional (albumin, BMI) markers was studied in 498 elderly subjects. Blood samples were taken from 164 healthy 20- to 60-year-old volunteer controls. A 3.5 years prospective follow-up study of mortality by age-related diseases was performed in n = 218 over 70-year-olds. Plasma Cu/Zn ratio was associated with all the inflammatory markers studied, as well as with serum albumin, and predicted 3.5 years mortality in subjects over 70. Plasma Cu/Zn was higher in women than men and increased with advancing age. Subjects with stable cardiovascular disease (CVD) displayed higher plasma Cu/Zn than those without, due mainly to increased plasma Cu. However, most of the age-related changes of Cu/Zn resulted from a progressive decline of plasma Zn. Cu/Zn ratio may be considered an important clinical inflammatory-nutritional biomarker as well as a significant predictor of all-cause mortality in over 70-year-olds.