Alterations in the Retinal Vascular Network and Structure in MOG Antibody-Associated Disease: An Optical Coherence Tomography Angiography Study
Alterations in the Retinal Vascular Network and Structure in MOG Antibody-Associated Disease: An Optical Coherence Tomography Angiography Study
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MOG 抗体相关疾病中视网膜血管网络和结构的改变：光学相干断层扫描血管造影研究
DOI：
10.1097/wno.0000000000001116
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Wang M
中科院分区：
文献类型：
--
作者：
Yu J;Huang Y;Quan C;Zhou L;ZhangBao J;Wu K;Zong Y;Zhou X;Wang M
补充数字内容在文本中可用。背景：测定髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）患者的视网膜血管密度。方法：25例MOGAD患者和20例健康对照者入选。MOGAD患者被分为髓鞘少突胶质细胞糖蛋白抗体（MOG-Ab）阳性眼，有视神经炎病史（ON; MOG-Ab-ON+组）或无ON病史（MOG-Ab-ON−组）。测量视功能、视网膜血管密度和厚度。结果如下：与健康眼和MOG-Ab-ON−眼相比，MOG-Ab-ON+眼的视网膜神经纤维层、视网膜旁神经节细胞和内网状层以及乳头周围和视网膜旁区域的血管密度显著降低（均P < 0.05）。ON发作次数的增加与这些变量的更大降低相关（所有P < 0.05）。有1 ~ 2次ON病史的患者视野平均偏差无明显降低，但视网膜神经纤维层厚度、视神经旁节细胞和内丛状层厚度、视乳头周围血管密度和视神经旁血管密度的相对降低分别达到33.1%、23.2%、17.0%和11.5%（均P < 0.05），调整其他变量后，平均偏差与乳头周围血管密度显著相关（P < 0.05）。最佳矫正视力与光学相干断层扫描变量无显著相关性（均P > 0.05）。结论：MOG-Ab相关ON与视网膜结构和血管密度的显著降低相关，而视觉功能无显著恶化。视乳头周围血管密度可预测MOG-Ab相关ON患者的视力预后。
Supplemental Digital Content is Available in the Text. Background: To determine retinal vessel density in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods: Twenty-five patients with MOGAD and 20 healthy participants were enrolled. Patients with MOGAD were divided into myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-positive eyes with a history of optic neuritis (ON; MOG-Ab-ON+ group) or without a history of ON (MOG-Ab-ON− group). Visual function, retinal vessel densities, and thickness were measured. Results: The retinal nerve fiber layer, parafoveal ganglion cell and inner plexiform layers, and vessel densities in the peripapillary and parafoveal areas were significantly decreased in the MOG-Ab-ON+ eyes compared with healthy eyes and MOG-Ab-ON− eyes (all P < 0.05). An increasing number of ON episodes was associated with greater decreases in these variables (all P < 0.05). Visual field mean deviation was not significantly decreased in patients with a history of 1 or 2 episodes of ON, although the relative decreases in retinal nerve fiber layer thickness, parafoveal ganglion cell and inner plexiform layer thickness, peripapillary vessel density, and parafoveal vessel density reached 33.1%, 23.2%, 17.0%, and 11.5% (all P < 0.05), respectively, in eyes with 2 episodes of ON. The mean deviation was significantly correlated with peripapillary vessel density (P < 0.05) after adjustment for other variables. Best-corrected visual acuity was not significantly correlated with optical coherence tomography variables (all P > 0.05). Conclusions: MOG-Ab-associated ON was associated with significant decreases in retinal structure and vessel density, without significant deteriorations in visual function. The peripapillary vessel density might predict the visual outcomes in patients with MOG-Ab-associated ON.
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影响因子：
4.7
作者：
Li B;Freeman RD
通讯作者：
Freeman RD
影响因子：
11.2
作者：
Bennett, Jeffrey L.;Lam, Chiwah;Kalluri, Sudhakar Reddy;Saikali, Philippe;Bautista, Katherine;Dupree, Cecily;Glogowska, Magdalena;Case, David;Antel, Jack P.;Owens, Gregory P.;Gilden, Don;Nessler, Stefan;Stadelmann, Christine;Hemmer, Bernhard
通讯作者：
Hemmer, Bernhard
影响因子：
4.4
作者：
Yu, Jian;Xiao, Kuanlin;Jiang, Chunhui
通讯作者：
Jiang, Chunhui
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
13.7
作者：
Yarmohammadi A;Zangwill LM;Diniz-Filho A;Suh MH;Yousefi S;Saunders LJ;Belghith A;Manalastas PI;Medeiros FA;Weinreb RN
通讯作者：
Weinreb RN