Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of Aging
Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of Aging
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DOI：
10.1159/000358901
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Zhang, Hong
中科院分区：
文献类型：
--
作者：
Kong, Yahui;Trabucco, Sally E.;Zhang, Hong
衰老的特征是细胞功能、有机体健康的逐渐下降以及与年龄相关的疾病和死亡的风险增加。衰老的一个潜在原因是随着年龄的增长，功能障碍的线粒体和氧化损伤的逐渐积累。在我们理解线粒体功能障碍和氧化应激在衰老和年龄相关疾病中的作用方面已经做出了相当大的努力。本章概述了氧化应激和线粒体功能障碍之间的相互作用，并讨论了它们对衰老，细胞死亡，干细胞功能，年龄相关疾病和寿命的影响。(C)2014 S. Karger AG，巴塞尔
Aging is characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-associated diseases and death. One potential cause of aging is the progressive accumulation of dysfunctional mitochondria and oxidative damage with age. Considerable efforts have been made in our understanding of the role of mitochondrial dysfunction and oxidative stress in aging and age-associated diseases. This chapter outlines the interplay between oxidative stress and mitochondrial dysfunction, and discusses their impact on senescence, cell death, stem cell function, age-associated diseases and longevity. (C) 2014 S. Karger AG, Basel