Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach
Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach
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DOI：
10.1021/ja8100243
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发表时间：
2009-04-29
影响因子：
15
通讯作者：
Riguera, Ricardo
中科院分区：
文献类型：
--
作者：
Lallana, Enrique;Fernandez-Megia, Eduardo;Riguera, Ricardo
通过菌株促进法(SPAAC)，有效地克服了铜(I)催化叠氮-炔[3+2]环加成反应(CuAAC)用于多糖基体系选择性点击功能化的局限性(解聚和铜污染)。在生理条件下用免疫球蛋白G修饰壳聚糖接枝聚乙二醇纳米结构的SPAAC标志着免疫纳米粒子的制备向前迈进了一步。
The limitations (depolymerization and Cu contamination) in the use of Cu(I)-catalyzed azide-alkyne [3 + 2] cycloadditions (CuAAC) for the selective click functionalization of polysaccharide-based systems have been efficiently surpassed using a strain-promoted approach (SPAAC). The SPAAC decoration of chitosan-g-poly(ethylene glycol) nanostructures with an immunoglobulin G under physiological conditions represents a step forward in the preparation of immunonanoparticles.