Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms.
Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms.
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DOI：
10.1093/nar/gkp032
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发表时间：
2009-02
影响因子：
14.9
通讯作者：
Gadelle D
中科院分区：
文献类型：
--
作者：
Forterre P;Gadelle D
拓扑异构酶是解决DNA双螺旋结构引起的拓扑问题的关键酶。因此，人们本应天真地期待在所有细胞生物体中找到同源的拓扑异构酶，这可以追溯到它们最后的共同祖先。然而，正如观察到的其他与DNA一起工作的酶一样，情况并非如此。系统基因组学分析表明，在生命的三个细胞域的最近的共同祖先中存在着不同的拓扑异构酶(其中一些存在于两个或三个结构域中)，而其他拓扑异构酶家族或亚家族是通过水平基因转移在特定的领域甚至特定的谱系中获得的。有趣的是，两组病毒编码的拓扑异构酶与细胞内的拓扑异构酶只有遥远的亲缘关系。为了解释这些观察，我们认为拓扑异构酶起源于祖先的病毒圈，并且不同的亚家族后来独立地转移到不同的古代细胞谱系。我们还提出，拓扑异构酶在现代基因组的起源和三个细胞域的出现中发挥了关键作用。
Topoisomerases are essential enzymes that solve topological problems arising from the double-helical structure of DNA. As a consequence, one should have naively expected to find homologous topoisomerases in all cellular organisms, dating back to their last common ancestor. However, as observed for other enzymes working with DNA, this is not the case. Phylogenomics analyses indicate that different sets of topoisomerases were present in the most recent common ancestors of each of the three cellular domains of life (some of them being common to two or three domains), whereas other topoisomerases families or subfamilies were acquired in a particular domain, or even a particular lineage, by horizontal gene transfers. Interestingly, two groups of viruses encode topoisomerases that are only distantly related to their cellular counterparts. To explain these observations, we suggest that topoisomerases originated in an ancestral virosphere, and that various subfamilies were later on transferred independently to different ancient cellular lineages. We also proposed that topoisomerases have played a critical role in the origin of modern genomes and in the emergence of the three cellular domains.
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影响因子：
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通讯作者：
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影响因子：
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