Epidemiologic Approaches for Studying Assisted Reproductive Technologies: Design, Methods, Analysis and Interpretation.
Epidemiologic Approaches for Studying Assisted Reproductive Technologies: Design, Methods, Analysis and Interpretation.
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DOI：
10.1007/s40471-017-0105-0
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发表时间：
2017-06
影响因子：
3.3
通讯作者：
Gaskins AJ
中科院分区：
文献类型：
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作者：
Messerlian C;Gaskins AJ
虽然自辅助生殖技术（ART）出现以来已经取得了相当大的进展，但对于临床医生和研究人员来说，该领域仍然是一个复杂和具有挑战性的领域。本综述讨论了与ART研究相关的一些最突出的问题，并尽可能就如何解决这些问题提出建议。迄今为止，已有500多万婴儿通过抗逆转录病毒疗法出生，占全世界所有出生人数的4%。随着技术的不断发展和治疗需求的增长，进行严格和及时的研究比以往任何时候都更加重要，以帮助指导安全有效的临床实践，并最大限度地减少对母亲和儿童的潜在短期和长期不良后果。ART研究将需要非常复杂的研究方法、设计和分析，这些方法、设计和分析植根于生殖流行病学框架，以改善未来的研究，并最终为所有生育力低下的夫妇及其子女带来更好的结果。
While considerable progress has been made since the advent of assisted reproductive technology (ART), the field remains a complex and challenging one for clinicians and researchers alike. This review discusses some of the most salient issues pertaining to the study of ART and whenever possible suggestions on how to address them. More than 5 million babies have been born through ART to date, representing up to 4% of all births worldwide. While technologies continue to evolve and demand for treatment grows, it is more important than ever to conduct rigorous and timely research to help guide clinical practice that is safe and effective, and that minimizes potential short- and long-term adverse outcomes to mother and child. ART research will require exceedingly more sophisticated research methods, designs, and analyses that are rooted in a reproductive epidemiological framework in order to improve future research and ultimately promote better outcomes for all subfertile couples and their children.