Failure of Posaconazole Therapy in a Renal Transplant Patient with Invasive Aspergillosis Due to Aspergillus fumigatus with Attenuated Susceptibility to Posaconazole
Failure of Posaconazole Therapy in a Renal Transplant Patient with Invasive Aspergillosis Due to Aspergillus fumigatus with Attenuated Susceptibility to Posaconazole
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DOI：
10.1128/aac.01544-10
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发表时间：
2011-07-01
影响因子：
4.9
通讯作者：
Verweij, Paul E.
中科院分区：
文献类型：
--
作者：
Kuipers, Saskia;Bruggemann, Roger J. M.;Verweij, Paul E.
我们报告的情况下，肾移植受者的侵袭性曲霉菌病由于烟曲霉菌耐伏立康唑和中度敏感泊沙康唑谁失败泊沙康唑治疗。泊沙康唑血药浓度表明浓度-时间曲线下面积与MIC的比值不利。泊沙康唑应谨慎用于由泊沙康唑敏感性减弱的菌株引起的侵袭性曲霉病，因为药物暴露可能不充分，导致治疗失败。
We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.