Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients.
Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients.
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DOI：
10.1038/sj.bjc.6603184
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发表时间：
2006-06-19
影响因子：
8.8
通讯作者：
Saad F
中科院分区：
文献类型：
--
作者：
Le Page C;Koumakpayi IH;Alam-Fahmy M;Mes-Masson AM;Saad F
我们研究了63例前列腺癌组织中Akt-1、Akt-2、Akt-3、磷酸化Akt蛋白的表达和定位与临床病理参数的关系。超过60%的癌组织过度表达Akt-1、Akt-2或Akt-3。细胞质Akt-1的表达与术后前列腺特异性抗原(PSA)复发风险高和PSA复发间隔短相关。细胞质Akt-2与预测预后的临床病理参数无明显相关性。细胞质Akt-3与激素难治性疾病进展和包膜外侵袭有关。Akt-1和Akt-2核表达与无淋巴结和神经侵袭等有利预后参数相关。Kaplan-Meier分析和Cox回归模型也显示Akt-1和Akt-2，而不是Akt-3或磷酸化Akt与PSA复发的风险显著相关。相比之下，核Akt-1与PSA复发的风险显著相关。多因素分析显示，临床分期、Gleason评分和癌组织胞浆Akt-1联合标志物是影响PSA复发的独立预后因素。这是第一个在前列腺癌患者中证明Akt-1亚型表达作为预后标志的特殊作用的报告，这取决于其定位。
We investigated the correlation between the expression and localisation of Akt-1, Akt-2, Akt-3, phospho-Akt proteins and the clinicopathological parameters in 63 prostate cancer specimens. More than 60% of cancerous tissues overexpressed Akt-1, Akt-2 or Akt-3. Cytoplasmic Akt-1 expression was correlated with a higher risk of postoperative prostate-specific antigen (PSA) recurrence and shorter PSA recurrence interval. Cytoplasmic Akt-2 did not show any significant correlation with clinicopathological parameters predicting outcomes. Cytoplasmic Akt-3 was associated with hormone-refractory disease progression and extracapsular invasion. Nuclear Akt-1 and Akt-2 expression were correlated with favourable outcome parameters such as absence of lymph node and perineural invasion. Kaplan–Meier analysis and Cox regression model also showed that Akt-1 and Akt-2, but not Akt-3 or phospho-Akt was associated with a significantly higher risk of PSA recurrence. In contrast, nuclear Akt-1 was significantly associated with a lower risk of PSA recurrence. Multivariate analysis revealed that clinical stage, Gleason score and the combined cytoplasmic nuclear Akt-1 marker in cancerous tissues were significant independent prognostic factors of PSA recurrence. This is the first report demonstrating in patients with prostate cancer and the particular role of Akt-1 isoform expression as a prognostic marker depending of its localisation.
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影响因子：
8.8
作者：
Gray, IC;Stewart, LMD;Phillips, SMA;Hamilton, JA;Gray, NE;Watson, GJ;Spurr, NK;Snary, D
通讯作者：
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