Phase-Amplitude Coupling of the Electroencephalogram in the Auditory Cortex in Schizophrenia
Phase-Amplitude Coupling of the Electroencephalogram in the Auditory Cortex in Schizophrenia
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DOI：
10.1016/j.bpsc.2017.09.001
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发表时间：
2018-01-01
影响因子：
5.9
通讯作者：
Spencer, Kevin M.
中科院分区：
文献类型：
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作者：
Hirano, Shogo;Nakhnikian, Alexander;Spencer, Kevin M.
背景：交叉频率的相互作用可以协调不同频率的神经回路。虽然精神分裂症（SZ）中与特定回路相关的神经振荡受损，但很少有研究检查交叉频率相互作用。本文研究了SZ患者和健康对照者（hc）脑电图的相幅耦合（PAC）。我们计算了40 hz听觉稳态刺激和休息基线期的PAC。我们假设SZ受试者在刺激过程中会表现出异常的θ / γ耦合，特别是在左听觉皮层，并且在刺激过程中高频耦合比休息时高。方法：我们重新分析了18例SZ和18例hc患者的资料。利用偶极子源定位估计听觉皮层脑电图活动。采用去偏PAC测度计算PAC，用广义Morse小波变换计算PAC。使用聚类校正排列测试确定PAC簇，并在方差分析中对多个测试进行校正。结果：总体而言，在听觉稳态反应期间，高β和高γ振幅的耦合更高，而在休息时，α / β PAC更高。SZ患者的Theta/alpha PAC高于hc患者。在hc中，θ / γ PAC向左半球偏侧，而在SZ受试者中没有偏侧。结论：涉及高频的PAC与SZ的状态相关，不存在异常。SZ患者的θ / α PAC增加与其他低频活动增加的证据一致。SZ患者的半球侧化θ / γ PAC减少，这与SZ患者左半球听觉皮层异常的证据一致。PAC可能为SZ和其他神经精神疾病的神经回路异常提供新的见解。
BACKGROUND: Cross-frequency interactions may coordinate neural circuits operating at different frequencies. While neural oscillations associated with particular circuits in schizophrenia (SZ) are impaired, few studies have examined cross-frequency interactions. Here we examined phase-amplitude coupling (PAC) in the electroencephalograms of individuals with SZ and healthy control subjects (HCs). We computed PAC during the baseline period of 40-Hz auditory steady-state stimulation and rest. We hypothesized that subjects with SZ would show abnormal theta/gamma coupling during stimulation, especially in the left auditory cortex, and coupling with high frequencies would be higher during stimulation than during rest.METHODS: We reanalyzed data from 18 subjects with SZ and 18 HCs. Auditory cortex electroencephalogram activity was estimated using dipole source localization. PAC was computed using the debiased PAC measure, calculated with the generalized Morse wavelet transform. PAC clusters were identified using cluster-corrected permutation testing and interrogated in analyses of variance with correction for multiple tests.RESULTS: Overall, coupling of high beta and gamma amplitude was higher during the auditory steady-state response, while alpha/beta PAC was higher during rest. Theta/alpha PAC was higher in subjects with SZ than in HCs. Theta/gamma PAC was lateralized to the left hemisphere in HCs but was not lateralized in subjects with SZ.CONCLUSIONS: PAC involving high frequencies was state dependent and not abnormal in SZ. Increased theta/alpha PAC in subjects with SZ was consistent with other evidence of increased low-frequency activity. Hemispheric lateralization of theta/gamma PAC was reduced in subjects with SZ, consistent with evidence for left hemisphere auditory cortex abnormalities in subjects with SZ. PAC may reveal new insights into neural circuitry abnormalities in SZ and other neuropsychiatric disorders.