Arterial spin labeling in patients with chronic cerebral artery steno-occlusive disease: correlation with 15O-PET
Arterial spin labeling in patients with chronic cerebral artery steno-occlusive disease: correlation with 15O-PET
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DOI：
10.1258/ar.2012.120450
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发表时间：
2013-02-01
期刊：
影响因子：
1.3
通讯作者：
Honda, Hiroshi
中科院分区：
文献类型：
--
作者：
Kamano, Hironori;Yoshiura, Takashi;Honda, Hiroshi
背景：脑动脉狭窄闭塞病变引起的动脉通过时间的异质性阻碍了动脉自旋标记（ASL）准确测量局部脑血流量。目的：通过与正电子发射断层扫描（PET）比较，评估ASL多次延迟时间采样测量局部脑血流的可行性，并与正电子发射断层扫描（PET）进行比较，并确定该ASL技术测量的区域动脉通过时间是否与区域平均通过时间（PET）相关。灌注压指数。材料与方法：16 例狭窄闭塞性疾病患者同时接受 ASL 和 O-15-PET 治疗。通过感兴趣区域分析获得通过 ASL 和 PET 测量的平均区域脑血流量、通过 ASL 测量的区域动脉通过时间和通过 PET 测量的区域平均通过时间。使用 Pearson 相关系数的绝对值和相对值测试 ASL 和 PET 测得的区域脑血流量之间的相关性，以及 ASL 测得的区域动脉通过时间和 PET 测得的区域平均通过时间之间的相关性。在控制 ASL 对局部脑血流的影响后，进行多变量回归分析，以检验 ASL 的区域动脉通过时间是否是 PET 建模区域平均通过时间的显着贡献者。结果：ASL 的区域脑血流与 PET 的区域脑血流之间的绝对值（r = 0.520，P < 0.0001）和相对值（r = 0.691，P < 0.0001）均呈显着正相关。 ASL 的区域动脉通过时间与 PET 的区域平均通过时间之间存在显着的正相关关系，无论是绝对值（r = 0.369，P = 0.0002）还是相对值（r = 0.443，P < 0.0001）。回归分析显示，在通过ASL控制局部脑血流后，通过ASL测量的区域动脉通过时间是通过PET模拟区域平均通过时间的重要因素（P = 0.0011）。结论：在脑动脉狭窄闭塞性疾病患者中，证实了使用ASL多重延迟时间采样进行局部脑血流测量的可行性。此外，有人建议绘制区域动脉传输时间图有可能检测血流动力学损伤。
Background: Heterogeneity of arterial transit time due to cerebral artery steno-occlusive lesions hampers accurate regional cerebral blood flow measurement by arterial spin labeling (ASL).Purpose: To assess the feasibility of regional cerebral blood flow measurement by ASL with multiple-delay time sampling in patients with steno-occlusive diseases by comparing with positron emission tomography (PET), and to determine whether regional arterial transit time measured by this ASL technique is correlated with regional mean transit time, a PET index of perfusion pressure.Material and Methods: Sixteen patients with steno-occlusive diseases received both ASL and O-15-PET. The mean regional cerebral blood flow measured by ASL and PET, regional arterial transit time by ASL, and regional mean transit time by PET were obtained by a region-of-interest analysis. Correlation between regional cerebral blood flow by ASL and that by PET, and correlation between regional arterial transit time by ASL and regional mean transit time by PET were tested using Pearson's correlation coefficient for both absolute and relative values. A multivariate regression analysis was performed to test whether regional arterial transit time by ASL was a significant contributor in modeling regional mean transit time by PET after controlling the effect of regional cerebral blood flow by ASL.Results: A significant positive correlation was found between regional cerebral blood flow by ASL and that by PET for both absolute (r = 0.520, P < 0.0001) and relative (r = 0.691, P < 0.0001) values. A significant positive correlation was found between regional arterial transit time by ASL and regional mean transit time by PET both for absolute (r = 0.369, P = 0.0002) and relative (r = 0.443, P < 0.0001) values. The regression analysis revealed that regional arterial transit time by ASL was a significant contributor in modeling regional mean transit time by PET after controlling regional cerebral blood flow by ASL (P = 0.0011).Conclusion: The feasibility of regional cerebral blood flow measurement using ASL with multiple-delay time sampling was confirmed in patients with cerebral artery steno-occlusive diseases. Moreover, it was suggested that mapping of regional arterial transit time has the potential to detect hemodynamic impairment.