Preparation of mesoverdohemochrome IXα dimethyl ester and Mössbauer spectra of related porphyrins
Preparation of mesoverdohemochrome IXα dimethyl ester and Mössbauer spectra of related porphyrins
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中色素血红素IXα二甲酯的制备及相关卟啉的穆斯堡尔谱
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
H. Sano
中科院分区：
文献类型：
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作者：
S. Saito;S. Sumita;K. Iwai;H. Sano
原胆绿素IX α二甲酯（8）经氢化得到中胆绿素IXα二甲酯（7）。5-氧杂中卟啉IX二甲酯四氟硼酸锌（6）是通过7与乙酸锌在乙酸酐中环化，然后用四氟硼酸钠水溶液处理而制备的。7在含少量吡啶的乙酸酐中与硫酸亚铁和氯化铁环合得到双（吡啶）中奥弗多血红素IXα二甲酯（4）。通过将过量的对甲苯磺酰基甲基异氰化物（TsCH 2NC）加入到4中，制备了双（对甲苯磺酰基甲基异氰化物）mesoverdohemochrome IXα二甲酯（5）。4和5与氨反应得到铁（III）5-氮杂中卟啉IX二甲酯（10）。双吡啶绿血红素配合物（4、13和14）的穆斯堡尔谱有双峰，其参数δ=0.41-0.43 mm s−1和ΔEQ=1.24-1.26 mm s−1，表明这些配合物的中心铁的氧化态是铁（II）。双（TsCH 2N）三氟甲烷
Mesobiliverdin IXα dimethyl ester (7) was obtained by hydrogenation of protobiliverdin IXα dimethyl ester (8). Zinc 5-oxamesoporphyrin IX dimethyl ester tetrafluoroborate (6) was prepared by the cyclization of 7 with zinc acetate in acetic anhydride followed by a treatment with aqueous sodium tetrafluoroborate. Bis(pyridine) mesoverdohemochrome IXα dimethyl ester (4) was obtained by the cyclization of 7 with both iron(II) sulfate and iron(III) chloride in acetic anhydride containing a small amount of pyridine. Bis(tosylmethyl isocyanide) mesoverdohemochrome IXα dimethyl ester (5) was prepared by the addition of excess tosylmethyl isocyanide (TsCH2NC) to 4. Both 4 and 5 reacted with ammonia to give iron(III) 5-azamesoporphyrin IX dimethyl ester (10). The Mossbauer spectra of bis(pyridine) verdohemochromes (4, 13, and 14) snowed doublet peaks having parameters of δ=0.41–0.43 mm s−1 and ΔEQ=1.24–1.26 mm s−1, indicating that the oxidation states of the central irons of these complexes are iron(II). Bis(TsCH2N...