Fractal activity generated independently by medullary sympathetic premotor and preganglionic sympathetic neurons.
Fractal activity generated independently by medullary sympathetic premotor and preganglionic sympathetic neurons.
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分形活动由髓质交感前运动神经元和节前交感神经元独立产生。
DOI：
10.1152/jn.00066.2003
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Gebber,GerardL
中科院分区：
文献类型：
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作者：
Orer,HakanS;Das,Mahasweta;Barman,SusanM;Gebber,GerardL
在颈脊髓横断麻醉的猫中，采用Fano因子分析来检验单个节前颈交感神经元（psn）和位于吻侧腹外侧髓质（RVLM）和尾侧髓质中叶的假定交感前运动神经元的峰值计数的时间尺度不变（分形）波动。髓质神经元表现出与心脏相关的活动，它们的轴突投射到脊髓，如反节律激活所证明的那样。方差对平均峰值计数比（Fano因子）绘制为用于计数峰值的窗口大小的函数。7个psn、8个RVLM神经元和8个raphe神经元的Fano因子曲线包含一个扩展到多个时间尺度的幂律关系。在这些情况下，原始时间序列的随机洗牌间隔消除了幂律关系。因此，幂律关系可以归因于峰间间隔之间的长期相关性，而不是简单地归因于不因数据变换而改变的间隔分布。由此可见，髓质的psn和交感前运动神经元可以独立产生分形放电模式。
In anesthetized cats with cervical spinal cord transection, Fano factor analysis was used to test for time-scale invariant (fractal) fluctuations in spike counts of single preganglionic cervical sympathetic neurons (PSNs) and putative sympathetic premotor neurons located in the rostral ventrolateral medulla (RVLM) and caudal medullary raphe. The medullary neurons exhibited cardiac-related activity, and their axons projected to the spinal cord, as demonstrated by antidromic activation. The variance-to-mean spike count ratio (Fano factor) was plotted as a function of the window size used to count spikes. The Fano factor curves for seven PSNs, eight RVLM neurons, and eight raphe neurons contained a power law relationship extending over more than one time scale. In these cases, random shuffling of the interspike intervals in the original time series eliminated the power law relationship. Thus the power law relationships can be attributed to long-range correlations among interspike intervals rather than simply to the distribution of the intervals that is not changed by shuffling the data. It is concluded that PSNs and sympathetic premotor neurons in the medulla can independently generate fractal firing patterns.