Genetic variants in oxytocinreceptor gene (OXTR) and childhood physical abuse collaborate to modify the risk of aggression in Chinese adolescents.
Genetic variants in oxytocinreceptor gene (OXTR) and childhood physical abuse collaborate to modify the risk of aggression in Chinese adolescents.
复制标题
催产素受体基因（OXTR）的遗传变异和儿童时期的身体虐待共同改变了中国青少年的攻击性风险。
DOI：
10.1016/j.jad.2017.12.024
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发表时间：
2017
影响因子：
6.6
通讯作者：
Yizhen Yu
中科院分区：
文献类型：
--
作者：
Yanmei Zhang;Chunxia Wu;Hongjuan Chang;Qiuge Yan;Linguo Wu;Shanshan Yan;Jjing Xiang;Wen Hao;Yizhen Yu
研究背景越来越多的证据表明，遗传和环境因素可能影响攻击易感性。然而，攻击性行为的病因仍然未知。与一些广泛研究的攻击性候选基因相比，对OXTR基因的了解很少。本研究的目的是确定是否OXTR基因变异与攻击风险，以及这些多态性是否表现出交互作用与儿童期虐待的攻击在中国青少年。方法共996名参与者，包括488例病例和488名对照。采用自评问卷测量攻击性、儿童期虐待。收集颊部细胞。使用SNP扫描进行基因分型。Logistic回归估计两个主要影响ofOXTR多态性和交互作用与儿童期虐待的攻击behaviors. ResultsWho携带rs 237885 TT基因型的参与者有较高的攻击风险相比，那些携带GG或GT基因型的隐性模型（OR=1.40，95%CI，1.04-1.89）后，控制潜在的混杂因素。此外，我们还发现该多态性与儿童期身体虐待对攻击风险具有协同加性交互作用。局限性本研究的受试者仅为男性，因此我们的发现和结论不能推广到女性。此外，本研究首次报道了OXTR基因多态性与儿童期身体虐待对中国青少年攻击行为的交互作用。
BackgroundAccumulating evidence suggests that genetic and environmental factors may influence aggression susceptibility. However, the etiology of aggressive behavior remains unknown. Compared to some extensively studied candidate genes of aggression, very little is known about the OXTR gene. The objective of this study was to determine whetherOXTRgenetic variants were associated with aggression risk and whether these polymorphisms showed interactive effects with childhood maltreatment on aggression in Chinese adolescents.MethodsA total of 996 participants including 488 cases and 488 controls were selected in our study. Aggression, childhood maltreatment were measured by self-reported questionnaire. Buccal cells were collected. Genotyping was performed using SNPscan. Logistic regressions were used to estimate both main effects ofOXTRpolymorphisms and the interactive effects with childhood maltreatment on aggressive behavior.ResultsParticipants who carried the rs237885 TT genotypes inOXTRhad a higher risk of aggression compared to those who carried GG or GT genotypes under the recessive model (OR=1.40, 95% CI, 1.04–1.89) after controlling for potential confounders. In addition, we also found that the polymorphism had a synergic additive interaction with childhood physical abuse on the aggression risk.LimitationsThe subjects in the present study were only males, thus our findings and conclusions could not be generalized to females.ConclusionsThe present study provides evidence thatOXTRgenetic variants may contribute to aggression susceptibility. Moreover, this is the first study reporting significant interactive effects ofOXTRpolymorphism and childhood physical abuse on aggressive behavior in Chinese adolescents.